PMID- 25588463
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20220408
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Linking)
VI  - 33
IP  - 2
DP  - 2015
TI  - Quercetin ameliorates hypobaric hypoxia-induced memory impairment through 
      mitochondrial and neuron function adaptation via the PGC-1alpha pathway.
PG  - 143-57
LID - 10.3233/RNN-140446 [doi]
AB  - PURPOSE: Acute hypobaric hypoxia (HH) causes persistent cognitive impairment, 
      affecting memory function specifically. Mitochondrial dysfunction and synaptic 
      morphological change were the prominent pathological features of HH exposure on 
      brain. Quercetin, a flavonoid found in fruits, vegetables, leaves and grains, is 
      reported to prevent ischemia induced by neuronal injury. This study investigated 
      the efficacy of quercetin to ameliorate HH-induced memory deficit. METHODS: Rats 
      were exposed to HH equivalent to 5000 m for 7 days in a decompression chamber and 
      received quercetin daily (50, 75 or 100 mg/kg.bw) via gavage during the period of 
      exposure. Cognitive performance was assessed by the Morris water maze test. In 
      vitro, the effect of quercetin was tested in hippocampus tissue. RESULTS: 
      Quercetin, especially at 100 mg/kg.bw, significantly reduced HH-induced memory 
      decline. Meanwhile, HH-induced hippocampus mitochondrial and synaptic lesions 
      were ameliorated by quercetin. Furthermore, quercetin regulated the expression of 
      sirtuin 1(Sirt1), PGC-1alpha, and the proteins related with mitochondrial biogenesis 
      and dynamics. Moreover, quercetin increased expression of fibronectin type III 
      domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), 
      showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation. 
      CONCLUSIONS: The results suggest quercetin has prophylactic potential for 
      amelioration of HH-induced memory impairment, which is associated with the 
      mitochondrial and neuronal adaptation in hippocampus.
FAU - Liu, Peng
AU  - Liu P
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Zou, Dan
AU  - Zou D
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Yi, Long
AU  - Yi L
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Chen, Mingliang
AU  - Chen M
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Gao, Yanxiang
AU  - Gao Y
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Zhou, Rui
AU  - Zhou R
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Zhang, Qianyong
AU  - Zhang Q
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Zhou, Yong
AU  - Zhou Y
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Zhu, Jundong
AU  - Zhu J
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Chen, Ka
AU  - Chen K
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
FAU - Mi, Mantian
AU  - Mi M
AD  - Research Center for Nutrition and Food Safety, Institute of Military Preventive 
      Medicine, Third Military Medical University, Chongqing Key Laboratory of 
      Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, 
      Chongqing, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, rat)
RN  - 0 (Fibronectins)
RN  - 0 (Nootropic Agents)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 0 (Transcription Factors)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Adaptation, Physiological/drug effects/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Fibronectins/metabolism
MH  - Hippocampus/drug effects/pathology/physiopathology
MH  - Hypoxia/*drug therapy/pathology/physiopathology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Memory Disorders/*drug therapy/pathology/physiopathology
MH  - Mitochondria/*drug effects/physiology
MH  - Neurons/*drug effects/pathology/physiology
MH  - Nootropic Agents/*pharmacology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Pressure/adverse effects
MH  - Quercetin/*pharmacology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Sirtuin 1/metabolism
MH  - Synapses/drug effects/pathology/physiology
MH  - Transcription Factors/metabolism
OTO - NOTNLM
OT  - Hypobaric hypoxia
OT  - PGC-1alpha
OT  - memory impairment
OT  - mitochondria
OT  - neuroprotection
OT  - quercetin
EDAT- 2015/01/16 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/16 06:00
PHST- 2015/01/16 06:00 [entrez]
PHST- 2015/01/16 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - V015X47710VRH8H1 [pii]
AID - 10.3233/RNN-140446 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2015;33(2):143-57. doi: 10.3233/RNN-140446.