PMID- 25590789
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20150715
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Linking)
VI  - 6
IP  - 7
DP  - 2015 Jul 15
TI  - 5-HT6 Receptor: A New Player Controlling the Development of Neural Circuits.
PG  - 951-60
LID - 10.1021/cn500326z [doi]
AB  - 5-HT6 receptor (5-HT6R) is a G protein-coupled receptor that has recently emerged 
      as a new regulator of neural development. In addition to the canonical Gs 
      adenylyl cyclase pathway, recent proteomics approaches reveal that 5-HT6R is able 
      to engage key developmental signaling pathways controlling neuronal circuit 
      formation, neuronal connectivity, and psychiatric-relevant behaviors. For 
      example, at early stages of neuronal development, expression of 5-HT6R 
      constitutively regulates the activity of the cyclin-dependent kinase (Cdk)5 and, 
      through this mechanism, controls cellular processes involved in circuit 
      formation, including neuronal migration and neurite outgrowth. In addition to the 
      Cdk5 pathway, 5-HT6R modulates a variety of key developmental targets such as 
      Fyn, Jab1, and mammalian target of rapamycin (mTOR). Engagement of developmental 
      pathways through 5-HT6R pharmacological manipulation has led to interesting new 
      therapeutic perspectives in the field of psychiatric-related disorders. Indeed, 
      5-HT6R blockade can rescue a pathological overactivation of the mTOR pathway 
      induced by early life insults in rodents and normalizes the associated social and 
      episodic memory deficits. Here, we review recent evidence supporting the notion 
      that 5-HT6R is at the interface of key developmental signaling pathways and a 
      novel actor in the orchestration of neural circuit formation.
FAU - Dayer, Alexandre G
AU  - Dayer AG
FAU - Jacobshagen, Moritz
AU  - Jacobshagen M
FAU - Chaumont-Dubel, Severine
AU  - Chaumont-Dubel S
FAU - Marin, Philippe
AU  - Marin P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150128
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Receptors, Serotonin)
RN  - 0 (serotonin 6 receptor)
SB  - IM
MH  - Animals
MH  - Brain/*growth & development/*metabolism
MH  - Cell Movement/physiology
MH  - Humans
MH  - Neural Pathways/growth & development/metabolism
MH  - Neurodevelopmental Disorders/metabolism
MH  - Neurons/*metabolism
MH  - Receptors, Serotonin/*metabolism
OTO - NOTNLM
OT  - 5-HT6R
OT  - CDK5
OT  - cortex
OT  - development
OT  - migration
EDAT- 2015/01/16 06:00
MHDA- 2016/04/20 06:00
CRDT- 2015/01/16 06:00
PHST- 2015/01/16 06:00 [entrez]
PHST- 2015/01/16 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - 10.1021/cn500326z [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2015 Jul 15;6(7):951-60. doi: 10.1021/cn500326z. Epub 2015 Jan 
      28.