PMID- 25591419
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20181202
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 37
IP  - 6
DP  - 2015 Jun
TI  - Protective effect of telmisartan on neurovascular unit and inflammasome in 
      stroke-resistant spontaneously hypertensive rats.
PG  - 491-501
LID - 10.1179/1743132815Y.0000000002 [doi]
AB  - OBJECTIVES: Hypertension is a crucial risk factor for both stroke and dementia, 
      including Alzheimer's disease (AD). We inspected the effect of telmisartan on the 
      neurovascular unit (NVU) and related inflammatory responses in spontaneously 
      hypertensive rat stroke resistant (SHR-SR) by observing the components of NVU 
      such as N-acetyl glucosamine oligomer (NAGO), collagen IV, astrocytes, and matrix 
      metalloproteinase-9 (MMP-9), as well as inflammasome NOD-like receptors family 
      protein 3 (NLRP3). METHODS: In the present study, we examined the effect of a 
      highly selective angiotensin type 1 (AT-1) antagonist of angiotensin 2 receptor 
      with high lipid solubility, telmisartan, on NVU and related inflammatory 
      responses in SHR-SR with a low dose (0.3 mg/kg/day) only for improving metabolic 
      syndrome, and a high dose (3 mg/kg/day) for improving both metabolic syndrome and 
      SHR-SR hypertension. RESULTS: Compared to normotensive Wistar rats, long-lasting 
      hypertension in SHR-SR disrupted NVU by changing immunohistological components 
      such as NAGO, collagen IV, astrocytes, and MMP-9. SHR-SR also strongly induced 
      AD-related inflammasome NLRP3 in neuronal cells with age. However, such NVU 
      disruption and inflammasome activation were greatly improved with dose-dependent 
      telmisartan treatments. DISCUSSION: These results suggest that telmisartan 
      comprehensively protected the NVU components by reducing inflammatory reactions 
      relative to AD in hypertensive rats, which could also preclude the risk of AD 
      under hypertension.
FAU - Liu, Wentao
AU  - Liu W
FAU - Yamashita, Toru
AU  - Yamashita T
FAU - Kurata, Tomoko
AU  - Kurata T
FAU - Kono, Syoichiro
AU  - Kono S
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
FAU - Deguchi, Kentaro
AU  - Deguchi K
FAU - Zhai, Yun
AU  - Zhai Y
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150116
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Benzoates)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, rat)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, rat)
RN  - U5SYW473RQ (Telmisartan)
SB  - IM
MH  - Aging/drug effects/metabolism
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Benzimidazoles/*pharmacology
MH  - Benzoates/*pharmacology
MH  - Carrier Proteins/metabolism
MH  - Cerebral Cortex/blood supply/drug effects/metabolism
MH  - Collagen/metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hypertension/*drug therapy/metabolism
MH  - Immunohistochemistry
MH  - Inflammasomes/*drug effects/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Neurovascular Coupling/*drug effects/physiology
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
MH  - Telmisartan
OTO - NOTNLM
OT  - AD,
OT  - Hypertension,
OT  - Inflammasome,
OT  - Neurovascular unit,
OT  - SHR-SR,
OT  - Telmisartan
EDAT- 2015/01/17 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/01/17 06:00
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - 10.1179/1743132815Y.0000000002 [doi]
PST - ppublish
SO  - Neurol Res. 2015 Jun;37(6):491-501. doi: 10.1179/1743132815Y.0000000002. Epub 
      2015 Jan 16.