PMID- 25592977
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20220311
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 225
IP  - 3
DP  - 2015 Feb 28
TI  - Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be 
      associated with relapse in cocaine-dependent patients.
PG  - 309-14
LID - S0165-1781(14)01012-9 [pii]
LID - 10.1016/j.psychres.2014.12.019 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is involved in cocaine craving in humans 
      and drug seeking in rodents. Based on this, the aim of this study was to explore 
      the possible role of serum BDNF in cocaine relapse in abstinent addicts. Forty 
      cocaine dependent subjects (DSM-IV criteria) were included in an inpatient 2 
      weeks abstinence program. Organic and psychiatric co-morbidities were excluded. 
      Two serum samples were collected for each subject at baseline and at after 14 
      abstinence days. After discharge, all cocaine addicts underwent a 22 weeks 
      follow-up, after which they were classified into early relapsers (ER) (resumed 
      during the first 14 days after discharge,) or late relapsers (LR) (resumed beyond 
      14 days after discharge). The only clinical differences between groups were the 
      number of consumption days during the last month before detoxification. Serum 
      BDNF levels increased significantly across the 12 days of abstinence in the LR 
      group (p=0.02), whereas in the ER group BDNF remained unchanged. In the ER group, 
      the change of serum BDNF during abstinence negatively correlated with the 
      improvement in depressive symptoms (p=0.02). These results suggest that BDNF has 
      a role in relapse to cocaine consumption in abstinent addicts, although the 
      underlying neurobiological mechanisms remain to be clarified.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Corominas-Roso, Margarida
AU  - Corominas-Roso M
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain. Electronic 
      address: mcoromin@vhebron.net.
FAU - Roncero, Carlos
AU  - Roncero C
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Biomedical 
      Network Research Center on Mental Health (CIBERSAM), Madrid, Spain; Department of 
      Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Catalonia, 
      Spain.
FAU - Daigre, Constanza
AU  - Daigre C
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
FAU - Grau-Lopez, Lara
AU  - Grau-Lopez L
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Department of 
      Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Catalonia, 
      Spain.
FAU - Ros-Cucurull, Elena
AU  - Ros-Cucurull E
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Department of 
      Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Catalonia, 
      Spain.
FAU - Rodriguez-Cintas, Laia
AU  - Rodriguez-Cintas L
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
FAU - Sanchez-Mora, Cristina
AU  - Sanchez-Mora C
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Biomedical 
      Network Research Center on Mental Health (CIBERSAM), Madrid, Spain; Psychiatric 
      Genetics Unit, Vall d׳Hebron Research Institute (VHIR), Barcelona, Catalonia, 
      Spain.
FAU - Lopez, Maria Victoria
AU  - Lopez MV
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
FAU - Ribases, Marta
AU  - Ribases M
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Biomedical 
      Network Research Center on Mental Health (CIBERSAM), Madrid, Spain; Psychiatric 
      Genetics Unit, Vall d׳Hebron Research Institute (VHIR), Barcelona, Catalonia, 
      Spain.
FAU - Casas, Miguel
AU  - Casas M
AD  - Department of Psychiatry, Vall d׳Hebron University Hospital (CIBERSAM), 
      Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; Biomedical 
      Network Research Center on Mental Health (CIBERSAM), Madrid, Spain; Department of 
      Psychiatry and Legal Medicine, Universitat Autonoma de Barcelona, Catalonia, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141220
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - *Cocaine
MH  - Cocaine-Related Disorders/*blood/psychology
MH  - Depression/blood/psychology
MH  - *Drug-Seeking Behavior
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Substance Withdrawal Syndrome/*blood/psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Abstinence
OT  - BDNF
OT  - Brain derived neurotrophic factor
OT  - Cocaine
OT  - Relapse
EDAT- 2015/01/17 06:00
MHDA- 2015/08/01 06:00
CRDT- 2015/01/17 06:00
PHST- 2014/03/12 00:00 [received]
PHST- 2014/12/06 00:00 [revised]
PHST- 2014/12/14 00:00 [accepted]
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - S0165-1781(14)01012-9 [pii]
AID - 10.1016/j.psychres.2014.12.019 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Feb 28;225(3):309-14. doi: 10.1016/j.psychres.2014.12.019. 
      Epub 2014 Dec 20.