PMID- 25593829
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150116
LR  - 20201001
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 19
IP  - 1
DP  - 2015 Jan-Feb
TI  - Correlations among obesity-associated gene polymorphisms, body composition, and 
      physical activity in patients with type 2 diabetes mellitus.
PG  - 66-71
LID - 10.4103/2230-8210.131757 [doi]
AB  - CONTEXT: Various studies have focused on the correlation between beta2-adrenergic 
      receptor (beta2AR), the beta3-adrenergic receptor (beta3AR), and the uncoupling protein 1 
      (UCP1) polymorphisms and obesity in patients with type 2 diabetes mellitus 
      (T2DM). AIMS: We examined the correlation between these polymorphisms and body 
      composition variables and between body composition and lifestyle variables in 
      Japanese T2DM patients. MATERIALS AND METHODS: Of the 48, T2DM outpatients in 
      Kanagawa prefecture recruited for participation, 32 (6 men and 26 women) met the 
      study criteria and were enrolled. Obesity-related gene polymorphisms were 
      identified in 3 genes beta3AR, UCP1, and beta2AR using the SMart amplification process. 
      Body composition variables were measured using a body composition analyzer. Data 
      regarding food and nutrient consumption, family history, and lifestyle factors 
      were collected via administration of questionnaires. RESULTS: Because significant 
      differences in body composition variables were found between men and women, 
      statistical analysis was performed with data from the 25 female subjects only. On 
      the basis of results of genetic testing, the subjects were divided into genotype 
      groups for two-group and three-group comparison. The beta3AR, UCP1, and beta2AR 
      polymorphisms and body composition significantly correlated with the percentage 
      of subcutaneous fat in both arms as compared with the wild type or hetero groups 
      with beta3AR polymorphisms. However, physical activity correlated with several body 
      composition variables. CONCLUSIONS: These results suggest that obesity in T2DM 
      patients is not the result of presence of an obesity-related gene polymorphism 
      but rather the absence of daily physical activity.
FAU - Saitoh, Sanae
AU  - Saitoh S
AD  - Division of Medical Nutrition, Faculty of Healthcare, Tokyo Healthcare 
      University, Tokyo, Japan.
FAU - Shimoda, Taeko
AU  - Shimoda T
AD  - Division of Medical Nutrition, Faculty of Healthcare, Tokyo Healthcare 
      University, Tokyo, Japan.
FAU - Hamamoto, Yukie
AU  - Hamamoto Y
AD  - Nakajima Internal Medicine Clinic, Yokosuka, Japan.
FAU - Nakaya, Yutaka
AU  - Nakaya Y
AD  - Department of Nutrition and Metabolism, Institute of Health Biosciences, The 
      University of Tokushima Graduate School, Tokushima, Japan.
FAU - Nakajima, Shigeru
AU  - Nakajima S
AD  - Nakajima Internal Medicine Clinic, Yokosuka, Japan.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC4287783
OTO - NOTNLM
OT  - obesity
OT  - type 2 diabetes
OT  - uncoupling protein 1
OT  - beta2AR
OT  - beta3AR gene polymorphism
COIS- Conflict of Interest: None declared.
EDAT- 2015/01/17 06:00
MHDA- 2015/01/17 06:01
PMCR- 2015/01/01
CRDT- 2015/01/17 06:00
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2015/01/17 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - IJEM-19-66 [pii]
AID - 10.4103/2230-8210.131757 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2015 Jan-Feb;19(1):66-71. doi: 
      10.4103/2230-8210.131757.