PMID- 25594210
OWN - NLM
STAT- MEDLINE
DCOM- 20151113
LR  - 20191210
IS  - 1873-3557 (Electronic)
IS  - 1386-1425 (Linking)
VI  - 140
DP  - 2015 Apr 5
TI  - Determination of L-thyroxine in pharmaceutical preparations by flow injection 
      analysis with chemiluminescence detection based on the enhancement of the 
      luminol-KMnO4 reaction in a micellar medium.
PG  - 162-5
LID - S1386-1425(14)01893-9 [pii]
LID - 10.1016/j.saa.2014.12.105 [doi]
AB  - A novel flow injection chemiluminescence (CL) method for the determination of 
      L-thyroxine in the presence of cethyltrimethylammonium bromide (CTMAB) surfactant 
      micelles is developed. The method is based on the significant signal enhancement 
      of L-thyroxine on the luminol-KMnO4 system in alkaline solution sensitized by 
      CTMAB. Parameters affecting the reproducibility and CL detection were optimized 
      systematically. Under the optimum conditions, the net CL intensity versus 
      L-thyroxine concentration was linear in the range of 5.0x10(-8)-3.0x10(-6) mol/L 
      with the detection limit of 8.9x10(-9) mol/L. The sample throughput is calculated 
      to be 140 samples/h and the relative standard deviations (RSDs) for 13 replicate 
      determination of 1.0x10(-6) L-thyroxine is 1.1%. The proposed method was 
      successfully applied for the determination of L-thyroxine in pharmaceutical 
      preparations with satisfactory recoveries in the range of 93.9-105.2%. This 
      rapid, sensitive, and high throughput method would provide a new tool for 
      L-thyroxine analysis.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Cao, Juntao
AU  - Cao J
AD  - College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 
      464000, PR China.
FAU - Wang, Hui
AU  - Wang H
AD  - College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 
      464000, PR China.
FAU - Liu, Yanming
AU  - Liu Y
AD  - College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 
      464000, PR China. Electronic address: liuym9518@sina.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150105
PL  - England
TA  - Spectrochim Acta A Mol Biomol Spectrosc
JT  - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JID - 9602533
RN  - 0 (Micelles)
RN  - 0 (Surface-Active Agents)
RN  - 00OT1QX5U4 (Potassium Permanganate)
RN  - 5EXP385Q4F (Luminol)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Equipment Design
MH  - Flow Injection Analysis/*instrumentation
MH  - Limit of Detection
MH  - Luminescence
MH  - Luminescent Measurements/*instrumentation
MH  - Luminol/*chemistry
MH  - Micelles
MH  - Potassium Permanganate/*chemistry
MH  - Reproducibility of Results
MH  - Surface-Active Agents/chemistry
MH  - Thyroxine/*analysis
OTO - NOTNLM
OT  - Cethyltrimethylammonium bromide
OT  - Chemiluminescence
OT  - Flow-injection
OT  - Luminol
OT  - l-thyroxine
EDAT- 2015/01/17 06:00
MHDA- 2015/11/14 06:00
CRDT- 2015/01/17 06:00
PHST- 2014/09/22 00:00 [received]
PHST- 2014/11/19 00:00 [revised]
PHST- 2014/12/28 00:00 [accepted]
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2015/11/14 06:00 [medline]
AID - S1386-1425(14)01893-9 [pii]
AID - 10.1016/j.saa.2014.12.105 [doi]
PST - ppublish
SO  - Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 5;140:162-5. doi: 
      10.1016/j.saa.2014.12.105. Epub 2015 Jan 5.