PMID- 25594495
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20150203
IS  - 1098-9064 (Electronic)
IS  - 0094-6176 (Linking)
VI  - 41
IP  - 1
DP  - 2015 Feb
TI  - Venous thromboembolism prophylaxis in critically ill patients.
PG  - 68-74
LID - 10.1055/s-0034-1398386 [doi]
AB  - Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary 
      embolism (PE), is recognized as a common complication in critically ill patients. 
      Risk factors including critical illness, mechanical ventilation, sedative 
      medications, and central venous catheter insertion are major contributing factors 
      to the high risk of VTE. Because of their impaired cardiopulmonary reserve, PE 
      arising from thrombosis in the deep veins of the calf that propagates proximally 
      is poorly tolerated by critically ill patients. Pharmacologic prophylaxis with 
      unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) has been 
      shown to decrease the incidence of VTE in medical, surgical, and critically ill 
      patients. As a result, over the past decades, VTE prophylaxis had become a 
      standard of preventive measure in the intensive care unit (ICU). In clinical 
      practice, the rate of VTE prophylaxis varies and may be inadequate in some 
      centers. A perception of a high bleeding risk in critically ill patients is a 
      major concern for most physicians that may lead to inadequate prophylaxis.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Boonyawat, Kochawan
AU  - Boonyawat K
AD  - Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 
      Thailand.
FAU - Crowther, Mark A
AU  - Crowther MA
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150116
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
SB  - IM
MH  - Critical Illness
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Venous Thromboembolism/drug therapy/*prevention & control
EDAT- 2015/01/17 06:00
MHDA- 2015/10/21 06:00
CRDT- 2015/01/17 06:00
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - 10.1055/s-0034-1398386 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2015 Feb;41(1):68-74. doi: 10.1055/s-0034-1398386. Epub 2015 
      Jan 16.