PMID- 25594732
OWN - NLM
STAT- MEDLINE
DCOM- 20160323
LR  - 20211203
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 95
IP  - 6
DP  - 2015 Jul
TI  - Malignant Melanoma Arising in Patients with a Large Congenital Melanocytic 
      Naevus: Retrospective Study of 10 Cases with Cytogenetic Analysis.
PG  - 686-90
LID - 10.2340/00015555-2049 [doi]
AB  - Large congenital melanocytic naevi (LCMN) represent the main risk factor for 
      development of melanoma in childhood. This retrospective study of 10 cases of 
      melanoma in patients with LCMN used fluorescence in situ hybridization (FISH) and 
      comparative genomic hybridization (CGH) (6 cases) to elucidate the clinical, 
      histological, and cytogenetic characteristics of this rare disorder. Six 
      melanomas were found within the LCMN, the others in lymph nodes, subcutis and 
      brain. The LCMN was located on the trunk in 8 cases, with satellite naevi in 6 
      cases. Two distinct groups emerged: 5 melanomas that developed before the age of 
      10 years and the other after 20 years. The mortality rate was 60% and clearly 
      correlated with clinical stage at diagnosis. Histological diagnosis was difficult 
      in only 2 patients in whom neither immunohistochemistry nor FISH were helpful. 
      Otherwise, CGH showed a high number of chromosomal aberrations leading to a 
      formal diagnosis.
FAU - Lacoste, Caroline
AU  - Lacoste C
AD  - Department of Pathology, Necker-Enfants Malades Hospital, APHP, Paris Descartes - 
      Sorbonne Paris Cite university, Institut Imagine, 75015 Paris, France.
FAU - Avril, Marie-Francoise
AU  - Avril MF
FAU - Frassati-Biaggi, Annonciade
AU  - Frassati-Biaggi A
FAU - Dupin, Nicolas
AU  - Dupin N
FAU - Chretien-Marquet, Bertrand
AU  - Chretien-Marquet B
FAU - Mahe, Emmanuel
AU  - Mahe E
FAU - Bodemer, Christine
AU  - Bodemer C
FAU - Vergier, Beatrice
AU  - Vergier B
FAU - de la Fouchardiere, Arnaud
AU  - de la Fouchardiere A
FAU - Fraitag, Sylvie
AU  - Fraitag S
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (PMEL protein, human)
RN  - 0 (gp100 Melanoma Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Axilla
MH  - Brain Neoplasms/genetics/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Groin
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Ki-67 Antigen/analysis
MH  - Lymph Nodes/pathology
MH  - Lymphatic Diseases/genetics/pathology
MH  - Male
MH  - Melanoma/genetics/*pathology
MH  - Melanoma-Specific Antigens/analysis
MH  - Middle Aged
MH  - Neoplasms, Second Primary/genetics/*pathology
MH  - Nevus, Pigmented/congenital/genetics/*pathology
MH  - Retrospective Studies
MH  - Skin Neoplasms/congenital/genetics/*pathology
MH  - Young Adult
MH  - gp100 Melanoma Antigen
EDAT- 2015/01/17 06:00
MHDA- 2016/03/24 06:00
CRDT- 2015/01/17 06:00
PHST- 2015/01/17 06:00 [entrez]
PHST- 2015/01/17 06:00 [pubmed]
PHST- 2016/03/24 06:00 [medline]
AID - 10.2340/00015555-2049 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2015 Jul;95(6):686-90. doi: 10.2340/00015555-2049.