PMID- 25595199
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20220330
IS  - 1742-4755 (Electronic)
IS  - 1742-4755 (Linking)
VI  - 12
DP  - 2015 Jan 16
TI  - A case-control observational study of insulin resistance and metabolic syndrome 
      among the four phenotypes of polycystic ovary syndrome based on Rotterdam 
      criteria.
PG  - 7
LID - 10.1186/1742-4755-12-7 [doi]
LID - 7
AB  - BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with an increased risk 
      of insulin resistance (IR), metabolic syndrome (MetS), impaired glucose tolerance 
      (IGT) and type 2 diabetes mellitus (T2DM). Metabolic aspects of the four PCOS 
      phenotypes remain to be fully defined. The aim of this study was to compare 
      metabolic parameters and insulin resistance among the four PCOS phenotypes 
      defined according to the Rotterdam criteria and to determine predictors of these 
      complications. METHODS: A total of 526 reproductive-aged women were included in 
      this observational case-control study. Of these, 263 were diagnosed as a PCOS 
      based on Rotterdam criteria and 263 infertile women with no evidence of PCOS were 
      recruited as controls. Biochemical, metabolic and insulin resistance parameters 
      were compared in the two groups and the frequency of MetS and IR were compared 
      among the four phenotypes. Data were analyzed for statistical significance using 
      Student's t-test and one way analysis of variance followed by a post-hoc test 
      (least significant difference). Chi-square tests were used to compare 
      proportions. Univariate and multivariate logistic regression analyses were also 
      applied. RESULTS: IR was identified in 112 (42.6%) of the PCOS women and 45 
      (17.1%) of the control (P <0.001). There were no significant differences in the 
      frequency of IR and MetS between the four PCOS phenotypes. Homeostatic model 
      assessment for IR (HOMA-IR) >/=3.8 was the most common IR parameter in PCOS and 
      control groups. Women with oligo-anovulation (O) and PCO morphology (P) had a 
      significantly lower level of 2-h postprandial insulin compared to women with O, P 
      and hyperandrogenism (H) phenotypes. Logistic regression analysis showed that 
      body mass index, waist circumference, triglyceride/high-density lipoprotein ratio 
      (cardiovascular risk), HOMA-IR and glucose abnormalities (T2DM) were associated 
      with increased risk of having MetS (P < 0.05). CONCLUSIONS: PCOS women with 
      (O + P) show milder endocrine and metabolic abnormalities. Although, there were 
      no significant differences in IR, MetS and glucose intolerance between the four 
      PCOS phenotypes, women with PCOS are at higher risk of impaired glucose tolerance 
      and undiagnosed diabetes.
FAU - Jamil, Avin S
AU  - Jamil AS
AD  - Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical 
      University, P.O. Box 383-65, Erbil, Iraq. avinsadiq_2008@yahoo.com.
FAU - Alalaf, Shahla K
AU  - Alalaf SK
AD  - Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical 
      University, P.O. Box 383-65, Erbil, Iraq. shahla_alaf@yahoo.com.
FAU - Al-Tawil, Namir G
AU  - Al-Tawil NG
AD  - Department of Community Medicine, College of Medicine, Hawler Medical University, 
      Erbil, Iraq. namiraltawil@yahoo.com.
FAU - Al-Shawaf, Talha
AU  - Al-Shawaf T
AD  - Women's Health Research Unit, Centre for Primary Care and Public Health, Barts 
      and The London Medical College, Queen Mary University, London, UK. 
      talhayas@aol.com.
AD  - Department of Primary Care and Public Health, Imperial College, London, UK. 
      talhayas@aol.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150116
PL  - England
TA  - Reprod Health
JT  - Reproductive health
JID - 101224380
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anthropometry/methods
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Iraq/epidemiology
MH  - Lipids/blood
MH  - Metabolic Syndrome/blood/epidemiology/*etiology/physiopathology
MH  - Phenotype
MH  - Polycystic Ovary Syndrome/blood/*complications/epidemiology/physiopathology
MH  - Young Adult
PMC - PMC4417246
EDAT- 2015/01/18 06:00
MHDA- 2016/04/06 06:00
PMCR- 2015/01/16
CRDT- 2015/01/18 06:00
PHST- 2014/10/14 00:00 [received]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/01/18 06:00 [entrez]
PHST- 2015/01/18 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
PHST- 2015/01/16 00:00 [pmc-release]
AID - 1742-4755-12-7 [pii]
AID - 364 [pii]
AID - 10.1186/1742-4755-12-7 [doi]
PST - epublish
SO  - Reprod Health. 2015 Jan 16;12:7. doi: 10.1186/1742-4755-12-7.