PMID- 25595986
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20191210
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 289
DP  - 2015 Mar 19
TI  - NGF but not BDNF overexpression protects hippocampal LTP from 
      beta-amyloid-induced impairment.
PG  - 114-22
LID - S0306-4522(15)00037-8 [pii]
LID - 10.1016/j.neuroscience.2014.12.063 [doi]
AB  - Two major neurotrophic factors, nerve growth factor (NGF) and brain-derived 
      neurotrophic factor (BDNF) are involved in a number of physiological processes 
      associated with neuronal growth, survival and plasticity. There are an increasing 
      number of papers demonstrating their ability to serve as neuroprotective 
      molecules under various pathological conditions. At the same time, it remains 
      unclear whether both NGF and BDNF have similar roles under pathological 
      conditions and their effects on the electrophysiological properties of neurons 
      after acute pathogen exposure. In the present paper we investigated the 
      neuroprotective role of these two neurotrophins in a well-characterized model of 
      beta-amyloid peptide (Abeta)-dependent impairment of long-term potentiation (LTP). 
      Using lentiviral gene delivery we performed long-term elevation of neurotrophin 
      expression in the dentate gyrus (DG) of rats. One week after virus injection 
      acute brain slices were incubated with beta-amyloid (25-35) for 1h and afterward 
      in vitro LTP induction was performed in medial perforant path-DG synapses. We 
      demonstrate that chronic elevation of NGF but not BDNF concentration protects LTP 
      induction from beta-amyloid action. Further inhibitory analysis suggests that the 
      effect of NGF is mediated by PI3K-signaling cascade.
CI  - Copyright (c) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ivanov, A D
AU  - Ivanov AD
AD  - Laboratory of Neurophysiology of Learning, Institute of Higher Nervous Activity 
      and Neurophysiology, Russian Academy of Sciences, 5A Butlerova Street, Moscow 
      117485, Russia. Electronic address: ivanov.andre.d@gmail.com.
FAU - Tukhbatova, G R
AU  - Tukhbatova GR
AD  - Laboratory of Molecular Neurobiology, Institute of Higher Nervous Activity and 
      Neurophysiology, Russian Academy of Sciences, 5A Butlerova Street, Moscow 117485, 
      Russia.
FAU - Salozhin, S V
AU  - Salozhin SV
AD  - Laboratory of Molecular Neurobiology, Institute of Higher Nervous Activity and 
      Neurophysiology, Russian Academy of Sciences, 5A Butlerova Street, Moscow 117485, 
      Russia.
FAU - Markevich, V A
AU  - Markevich VA
AD  - Laboratory of Neurophysiology of Learning, Institute of Higher Nervous Activity 
      and Neurophysiology, Russian Academy of Sciences, 5A Butlerova Street, Moscow 
      117485, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150113
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chromones)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Morpholines)
RN  - 0 (Peptide Fragments)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (amyloid beta-protein (25-35))
RN  - 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Amyloid beta-Peptides/metabolism/*toxicity
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Chromones/pharmacology
MH  - Dentate Gyrus/drug effects/*physiopathology
MH  - Enzyme Inhibitors/pharmacology
MH  - Gene Transfer Techniques
MH  - Genetic Vectors
MH  - HEK293 Cells
MH  - Humans
MH  - Lentivirus/genetics
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Morpholines/pharmacology
MH  - Nerve Growth Factor/genetics/*metabolism
MH  - Peptide Fragments/metabolism/*toxicity
MH  - Perforant Pathway/drug effects/physiopathology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Tissue Culture Techniques
OTO - NOTNLM
OT  - BDNF
OT  - LTP
OT  - NGF
OT  - beta-amyloid
OT  - neuroprotection
OT  - plasticity
EDAT- 2015/01/18 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/18 06:00
PHST- 2014/08/28 00:00 [received]
PHST- 2014/12/22 00:00 [revised]
PHST- 2014/12/23 00:00 [accepted]
PHST- 2015/01/18 06:00 [entrez]
PHST- 2015/01/18 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0306-4522(15)00037-8 [pii]
AID - 10.1016/j.neuroscience.2014.12.063 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Mar 19;289:114-22. doi: 10.1016/j.neuroscience.2014.12.063. 
      Epub 2015 Jan 13.