PMID- 25596254
OWN - NLM
STAT- MEDLINE
DCOM- 20150311
LR  - 20151119
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 143
IP  - 2
DP  - 2015 Feb
TI  - Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma.
PG  - 274-82; quiz 307
LID - 10.1309/AJCP06VIKFMTRCXD [doi]
AB  - OBJECTIVES: Mantle cell lymphoma in situ (MCLIS) consists of immunophenotypically 
      defined but histologically inapparent neoplastic cells restricted to narrow 
      mantle zones, without expansion or invasion beyond the mantle zone. We report a 
      unique case of MCLIS associated with a much more manifest nodal marginal zone 
      lymphoma (MZL) in an inguinal lymph node, porta hepatis lymph node, and bone 
      marrow. METHODS: Biopsies from all three locations were evaluated using standard 
      H&E-stained sections, immunohistochemistry, flow cytometry, metaphase 
      cytogenetics, and/or fluorescence in situ hybridization (FISH). RESULTS: This 
      case is unique for three reasons. First, the histologically covert mantle cell 
      lymphoma was multifocal, detected in all three locations using one or more of 
      flow cytometry, immunohistochemistry, cytogenetics, and FISH. Second, the MCLIS 
      was always accompanied by a more histologically dominant MZL. Third, where 
      evaluable, it did not grow in an appreciable mantle zone distribution, presumably 
      due to destruction of the normal nodal architecture by the neoplastic MZL cells 
      and the resulting absence of recognizable follicles and mantle zones. 
      CONCLUSIONS: This unique case provides new insight into the pathogenesis of 
      MCLIS.
CI  - Copyright(c) by the American Society for Clinical Pathology.
FAU - Sloan, Caroline
AU  - Sloan C
AD  - From the Department of Pathology and Laboratory Medicine, Perelman School of 
      Medicine, Hospital of the University of Pennsylvania, Philadelphia, and.
FAU - Xiong, Qun-Bin
AU  - Xiong QB
AD  - From the Department of Pathology and Laboratory Medicine, Perelman School of 
      Medicine, Hospital of the University of Pennsylvania, Philadelphia, and.
FAU - Crivaro, Anne
AU  - Crivaro A
AD  - From the Department of Pathology and Laboratory Medicine, Perelman School of 
      Medicine, Hospital of the University of Pennsylvania, Philadelphia, and.
FAU - Steinman, Sharon
AU  - Steinman S
AD  - St Luke's Hospital at St Luke's University Health Network, Allentown, PA.
FAU - Bagg, Adam
AU  - Bagg A
AD  - From the Department of Pathology and Laboratory Medicine, Perelman School of 
      Medicine, Hospital of the University of Pennsylvania, Philadelphia, and 
      adambagg@mail.med.upenn.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Composite Lymphoma/*pathology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Lymphoma, B-Cell, Marginal Zone/*pathology
MH  - Lymphoma, Mantle-Cell/*pathology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
OTO - NOTNLM
OT  - Composite lymphoma
OT  - Mantle cell lymphoma in situ
OT  - Marginal zone lymphoma
EDAT- 2015/01/18 06:00
MHDA- 2015/03/12 06:00
CRDT- 2015/01/18 06:00
PHST- 2015/01/18 06:00 [entrez]
PHST- 2015/01/18 06:00 [pubmed]
PHST- 2015/03/12 06:00 [medline]
AID - 143/2/274 [pii]
AID - 10.1309/AJCP06VIKFMTRCXD [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2015 Feb;143(2):274-82; quiz 307. doi: 
      10.1309/AJCP06VIKFMTRCXD.