PMID- 25596877
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20151119
IS  - 1618-0372 (Electronic)
IS  - 0065-1281 (Linking)
VI  - 117
IP  - 2
DP  - 2015 Mar
TI  - Effects of systemic Thalidomide and intracerebroventricular Etanercept and 
      Infliximab administration in a Streptozotocin induced dementia model in rats.
PG  - 176-81
LID - S0065-1281(14)00290-6 [pii]
LID - 10.1016/j.acthis.2014.12.002 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) upregulation enhances amyloid beta (Abeta) induced 
      neurotoxicity in Alzheimer's disease (AD). Intracerebroventricular streptozotocin 
      (STZ) administration causes pathological changes and cognitive deficits similar 
      to those seen in AD by causing impairment of brain glucose and energy metabolism. 
      Recent reports indicate a protective role of Thalidomide, Etanercept, and 
      Infliximab, all of which have anti-TNF-alpha activity, against cognitive and 
      neuropathological changes in experimental and clinical studies. We aimed to 
      investigate the protective effects of Thalidomide, Etanercept, and Infliximab in 
      a rat model of intracerebroventricular STZ-induced dementia. Sprague-Dawley rats 
      (250-300g) were separated to sham (n=6) and STZ (n=24) groups. The STZ group was 
      divided into four groups (STZ, STZ-thalidomide, STZ-etanercept, and 
      STZ-infliximab). Morris's water maze (MWM) and passive avoidance (PA) tests were 
      performed. At the end of the third week, brain tissues were obtained. 
      Histopathological analysis, immunohistochemistry, and electron microscopic 
      examinations were done. The improvement performance of the STZ group was 
      significantly reduced in the MWM test (p<0.001). Compared with the STZ, 
      STZ-thalidomide, STZ-etanercept, and STZ-infliximab groups had significantly 
      better performance (p<0.001, <0.05 and <0.05, respectively) in the MWM test. STZ 
      administration caused a significant decrease in the mean escape latency in PA 
      reflex (p<0.001). Thalidomide, Etanercept, and Infliximab were associated with 
      better PA reflexes compared to the STZ group (p<0.001 for all). Morphological and 
      immunohistochemical results showed increased neurodegenerative changes compared 
      to sham group. Our findings are in line with the findings reported in the 
      literature and encourage further studies with TNF-alpha antagonists, in particular 
      Thalidomide.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Kubra Elcioglu, H
AU  - Kubra Elcioglu H
AD  - Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, 
      Turkey. Electronic address: Kubra.elcioglu@marmara.edu.tr.
FAU - Kabasakal, Levent
AU  - Kabasakal L
AD  - Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, 
      Turkey.
FAU - Tufan, Fatih
AU  - Tufan F
AD  - Department of Internal Medicine, Division of Geriatrics School of Medicine, 
      Istanbul University, Istanbul, Turkey. Electronic address: fatihtufan@gmail.com.
FAU - Elcioglu, Omer H
AU  - Elcioglu OH
AD  - School of Dentistry, Istanbul University, Istanbul, Turkey.
FAU - Solakoglu, Seyhun
AU  - Solakoglu S
AD  - Department of Histology and Embryology, School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Kotil, Tugba
AU  - Kotil T
AD  - Department of Histology and Embryology, School of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Karan, Mehmet Akif
AU  - Karan MA
AD  - Department of Internal Medicine, Division of Geriatrics School of Medicine, 
      Istanbul University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150114
PL  - Germany
TA  - Acta Histochem
JT  - Acta histochemica
JID - 0370320
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 4Z8R6ORS6L (Thalidomide)
RN  - 5W494URQ81 (Streptozocin)
RN  - B72HH48FLU (Infliximab)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*pharmacology
MH  - *Dementia/chemically induced/physiopathology/prevention & control
MH  - Disease Models, Animal
MH  - Etanercept
MH  - Immunoglobulin G/*pharmacology
MH  - Infliximab
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Tumor Necrosis Factor
MH  - Streptozocin/*toxicity
MH  - Thalidomide/*pharmacology
OTO - NOTNLM
OT  - Etanercept
OT  - Infliximab
OT  - Rat dementia model
OT  - Streptozotocin
OT  - Thalidomide
EDAT- 2015/01/19 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/01/19 06:00
PHST- 2014/09/23 00:00 [received]
PHST- 2014/12/03 00:00 [revised]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2015/01/19 06:00 [entrez]
PHST- 2015/01/19 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S0065-1281(14)00290-6 [pii]
AID - 10.1016/j.acthis.2014.12.002 [doi]
PST - ppublish
SO  - Acta Histochem. 2015 Mar;117(2):176-81. doi: 10.1016/j.acthis.2014.12.002. Epub 
      2015 Jan 14.