PMID- 25597022 OWN - NLM STAT- MEDLINE DCOM- 20150925 LR - 20200330 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) VI - 25 IP - 4 DP - 2015 Apr TI - Extent of late gadolinium enhancement at right ventricular insertion points in patients with hypertrophic cardiomyopathy: relation with diastolic dysfunction. PG - 1190-200 LID - 10.1007/s00330-014-3390-8 [doi] AB - OBJECTIVES: Our aim was to examine the association between the extent of late gadolinium enhancement (LGE) at right ventricular insertion points (RVIP) and left ventricular (LV) functional parameters in patients with hypertrophic cardiomyopathy (HCM). METHODS: Sixty-one HCM patients underwent echocardiography and cardiovascular magnetic resonance (CMR) within one week. Mitral annular velocities (E/E') were obtained from echocardiography; LV ejection fraction (EF), LV mass index, LV wall maximal thickness, and left atrial volume index (LAVI) were obtained from MR. LGE extent was quantified (proportion of total LV myocardial mass) according to location: % RVIP-LGE and % non-RVIP-LGE. RESULTS: Although LGE was commonly present in both apical (74 %) and non-apical HCMs (88 %) (p = 0.163), RVIP-LGE was more frequent (86 % vs. 47 %, p = 0.002) in non-apical HCMs in which E/E' was significantly higher (19.23 +/- 8.40 vs. 13.13 +/- 5.06, p = 0.009). In addition, RVIP-LGE extent was associated with LV diastolic dysfunction (r = 0.45, p < 0.001 for E/E'; r = 0.53, p < 0.001 for LAVI) and lower LVEF (r = -0.42, p = 0.001). There was no correlation between non-RVIP-LGE extent and other parameters. Multiple linear regression analysis revealed RVIP-LGE extent as an independent predictor of E/E' (beta = 0.45, p < 0.001) and LAVI in HCM patients (beta = 0.53, p < 0.001). CONCLUSIONS: The extent of LGE at RVIPs in HCM patients is associated with increased estimated LV filling pressure and chronic diastolic burden. KEY POINTS: * Late gadolinium enhancement at RV insertion points is frequently seen in HCM. * RVIP-LGE extent is correlated with increased estimated LV filling pressure in HCM. * Non-RVIP-LGE extent did not show any association with LV diastolic dysfunction. FAU - Zhu, Yinsu AU - Zhu Y AD - Department of Radiology, Seoul National University Hospital, 28 Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea. FAU - Park, Eun-Ah AU - Park EA FAU - Lee, Whal AU - Lee W FAU - Kim, Hyung-Kwan AU - Kim HK FAU - Chu, Ajung AU - Chu A FAU - Chung, Jin Wook AU - Chung JW FAU - Park, Jae Hyung AU - Park JH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150118 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Aged MH - Cardiomyopathy, Hypertrophic/*complications/*diagnosis MH - Contrast Media MH - Diastole MH - Echocardiography MH - Female MH - *Gadolinium MH - Gadolinium DTPA MH - Heart Ventricles/diagnostic imaging/pathology MH - Humans MH - Image Enhancement/*methods MH - Linear Models MH - Male MH - Middle Aged MH - Myocardium/pathology MH - Retrospective Studies MH - Ventricular Dysfunction, Left/*complications/*diagnosis MH - Young Adult EDAT- 2015/01/19 06:00 MHDA- 2015/09/26 06:00 CRDT- 2015/01/19 06:00 PHST- 2013/11/25 00:00 [received] PHST- 2014/08/07 00:00 [accepted] PHST- 2014/07/29 00:00 [revised] PHST- 2015/01/19 06:00 [entrez] PHST- 2015/01/19 06:00 [pubmed] PHST- 2015/09/26 06:00 [medline] AID - 10.1007/s00330-014-3390-8 [doi] PST - ppublish SO - Eur Radiol. 2015 Apr;25(4):1190-200. doi: 10.1007/s00330-014-3390-8. Epub 2015 Jan 18.