PMID- 25597473
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20150916
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 132
IP  - 4
DP  - 2015 Oct
TI  - Association between serum lipids and membrane fatty acids and clinical 
      characteristics in patients with schizophrenia.
PG  - 293-300
LID - 10.1111/acps.12388 [doi]
AB  - OBJECTIVE: Earlier reports indicate that patients with schizophrenia have altered 
      lipid levels in serum and cell membranes. The purpose of this study was to 
      determine the relationship between clinical characteristics and serum and 
      membrane lipids. METHOD: Fifty-five patients with schizophrenia and 51 healthy 
      controls were included. The patients were characterized with Positive and 
      Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF). Serum 
      lipids [high- and low-density lipoprotein cholesterol (HDL, LDL) and triglyceride 
      (TG)] and erythrocyte polyunsaturated fatty acids (PUFA) were measured. RESULTS: 
      Among the participants with schizophrenia, there was a significant correlation 
      between serum triglyceride levels and PANSS-positive symptoms (r = 0.28, P = 
      0.04), GAF-S (r = -0.48, P = 0.001) and GAF-F (r = -0.32, P = 0.01), and between 
      HDL level and GAF-S (r = 0.37, P = 0.008) and GAF-F (r = 0.28, P = 0.04). 
      Long-chain PUFA were significantly associated with PANSS-negative symptoms (r = 
      0.52, P < 0.001), GAF-S (r = -0.32, P = 0.02), and GAF-F (r = -0.29, P = 0.04). 
      The patients with schizophrenia had significantly higher TG (P < 0.001) and lower 
      HDL (P < 0.001) levels than healthy controls. HDL was also lower in the subgroup 
      (n = 11) not receiving antipsychotic medication (P = 0.02). CONCLUSION: The 
      results suggest associations between lipid profile and clinical characteristics. 
      This may indicate a role for lipid biology in schizophrenia pathophysiology.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Solberg, D K
AU  - Solberg DK
AD  - Institute for Military Psychiatry, Norwegian Defense Medical Services, Oslo, 
      Norway.
AD  - Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
FAU - Bentsen, H
AU  - Bentsen H
AD  - Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
FAU - Refsum, H
AU  - Refsum H
AD  - Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
FAU - Andreassen, O A
AU  - Andreassen OA
AD  - NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway.
AD  - Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20150116
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - 0 (Fatty Acids)
RN  - 0 (Membrane Lipids)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Dyslipidemias/blood/psychology
MH  - Fatty Acids/*blood
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Membrane Lipids/*blood
MH  - Middle Aged
MH  - Schizophrenia/*blood
MH  - Social Class
OTO - NOTNLM
OT  - dyslipidemia
OT  - membrane lipids
OT  - schizophrenia
OT  - symptom levels
EDAT- 2015/01/20 06:00
MHDA- 2016/06/04 06:00
CRDT- 2015/01/20 06:00
PHST- 2014/12/10 00:00 [accepted]
PHST- 2015/01/20 06:00 [entrez]
PHST- 2015/01/20 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
AID - 10.1111/acps.12388 [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2015 Oct;132(4):293-300. doi: 10.1111/acps.12388. Epub 2015 
      Jan 16.