PMID- 25597656
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20220418
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 51
DP  - 2015 Apr
TI  - Localized connectivity in depression: a meta-analysis of resting state functional 
      imaging studies.
PG  - 77-86
LID - S0149-7634(15)00008-1 [pii]
LID - 10.1016/j.neubiorev.2015.01.006 [doi]
AB  - Resting-state fMRI studies investigating the pathophysiology of depression have 
      identified prominent abnormalities in large-scale brain networks. However, it is 
      unclear if localized dysfunction of specialized brain regions contribute to 
      network-level abnormalities. We employed a meta-analytical procedure and reviewed 
      studies conducted in China investigating changes in regional homogeneity (ReHo), 
      a measure of localized intraregional connectivity, from resting-state fMRI in 
      depression. Exploiting the statistical power gained from pooled analysis, we also 
      investigated the effects of age, gender, illness duration and treatment on ReHo. 
      The medial prefrontal cortex (MPFC) showed the most robust and reliable increase 
      in ReHo in depression, with greater abnormality in medication-free patients with 
      multiple episodes. Brain networks that relate to this region have been identified 
      previously to show aberrant connectivity in depression, and we propose that the 
      localized neuronal inefficiency of MPFC exists alongside wider network level 
      disruptions involving this region.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Iwabuchi, Sarina J
AU  - Iwabuchi SJ
AD  - Centre for Translational Neuroimaging, Division of Psychiatry & Applied 
      Psychology, Institute of Mental Health, University of Nottingham, Triumph Road, 
      Nottingham NG7 2TU, UK. Electronic address: Sarina.Iwabuchi@nottingham.ac.uk.
FAU - Krishnadas, Rajeev
AU  - Krishnadas R
AD  - Psychological Medicine, Sackler Institute, Neurology Block SGH, University of 
      Glasgow, Glasgow G51 4TF, UK. Electronic address: 
      Rajeev.Krishnadas@glasgow.ac.uk.
FAU - Li, Chunbo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China. 
      Electronic address: chunbo_li@163.com.
FAU - Auer, Dorothee P
AU  - Auer DP
AD  - Division of Imaging and Radiological Sciences, University of Nottingham, 
      Nottingham, UK. Electronic address: Dorothee.Auer@nottingham.ac.uk.
FAU - Radua, Joaquim
AU  - Radua J
AD  - Institute of Psychiatry, King's College London, UK; FIDMAG Germanes 
      Hospitalaries, CIBERSAM, Barcelona, Spain. Electronic address: 
      Joaquim.Radua@kcl.ac.uk.
FAU - Palaniyappan, Lena
AU  - Palaniyappan L
AD  - Centre for Translational Neuroimaging, Division of Psychiatry & Applied 
      Psychology, Institute of Mental Health, University of Nottingham, Triumph Road, 
      Nottingham NG7 2TU, UK; Nottinghamshire Healthcare NHS Trust, Nottingham, UK. 
      Electronic address: Lena.Palaniyappan@nottingham.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20150116
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Depressive Disorder/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/physiopathology
MH  - Rest
OTO - NOTNLM
OT  - Connectivity
OT  - Depression
OT  - Effect size - signed differential mapping
OT  - Regional homogeneity
OT  - Resting-state fMRI
EDAT- 2015/01/20 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/20 06:00
PHST- 2014/06/30 00:00 [received]
PHST- 2014/11/10 00:00 [revised]
PHST- 2015/01/08 00:00 [accepted]
PHST- 2015/01/20 06:00 [entrez]
PHST- 2015/01/20 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0149-7634(15)00008-1 [pii]
AID - 10.1016/j.neubiorev.2015.01.006 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2015 Apr;51:77-86. doi: 10.1016/j.neubiorev.2015.01.006. 
      Epub 2015 Jan 16.