PMID- 25597823
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20211203
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 70
IP  - 6
DP  - 2015 Jun
TI  - Immune reconstitution inflammatory syndrome in neutropenic patients with invasive 
      pulmonary aspergillosis.
PG  - 659-67
LID - S0163-4453(15)00027-4 [pii]
LID - 10.1016/j.jinf.2014.12.020 [doi]
AB  - OBJECTIVES: Clinical and radiologic deterioration is sometimes observed during 
      neutrophil recovery in patients with invasive pulmonary aspergillosis (IPA). This 
      deterioration can be caused by immune reconstitution inflammatory syndrome (IRIS) 
      as well as by progression of the IPA. However, there is limited data on IRIS in 
      neutropenic patients. METHODS: Over a 6-year period, adult patients with 
      neutropenia who met the criteria for probable or proven IPA by the revised 
      EORTC/MSG definition were retrospectively enrolled. IRIS was defined as de novo 
      appearance or worsening of radiologic pulmonary findings temporally related to 
      neutrophil recovery, with evidence of a decrease of 50% in serum galactomannan 
      level. RESULTS: Of 153 patients, 36 (24%, 95% CI 18%-31%) developed IRIS during 
      neutrophil recovery. More of these patients received voriconazole than did those 
      with non-IRIS (42% vs. 25%, P = 0.05). Thirty- and ninety-day mortalities were 
      lower in the patients with IRIS than in those with non-IRIS (11% vs. 33%, P = 
      0.01, and 33% vs. 58%, P = 0.01, respectively). CONCLUSION: IRIS is relatively 
      common among neutropenic patients with IPA, occurring in about one quarter of 
      such patients. It is associated with voriconazole use and has a good prognosis.
CI  - Copyright (c) 2015 The British Infection Association. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Jung, Jiwon
AU  - Jung J
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea.
FAU - Hong, Hyo-Lim
AU  - Hong HL
AD  - Division of Infectious Diseases, Department of Internal Medicine, Daegu Catholic 
      University Medical Center, Daegu, Republic of Korea.
FAU - Lee, Sang-Oh
AU  - Lee SO
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea.
FAU - Choi, Sang-Ho
AU  - Choi SH
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea.
FAU - Kim, Yang Soo
AU  - Kim YS
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea.
FAU - Woo, Jun Hee
AU  - Woo JH
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea.
FAU - Kim, Sung-Han
AU  - Kim SH
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, University of Ulsan, Seoul, Republic of Korea. Electronic 
      address: kimsunghanmd@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150115
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Antifungal Agents)
RN  - 0 (Mannans)
RN  - 11078-30-1 (galactomannan)
RN  - JFU09I87TR (Voriconazole)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
CIN - J Infect. 2015 Jun;70(6):563-4. PMID: 25659762
MH  - Antifungal Agents/*therapeutic use
MH  - Female
MH  - Galactose/analogs & derivatives
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/mortality
MH  - Invasive Pulmonary Aspergillosis/*complications/mortality
MH  - Lung/pathology
MH  - Male
MH  - Mannans/blood
MH  - Middle Aged
MH  - Neutropenia/*complications
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Voriconazole/*therapeutic use
OTO - NOTNLM
OT  - Immune reconstitution inflammatory syndrome
OT  - Invasive pulmonary aspergillosis
OT  - Neutropenia
EDAT- 2015/01/20 06:00
MHDA- 2017/04/18 06:00
CRDT- 2015/01/20 06:00
PHST- 2014/10/29 00:00 [received]
PHST- 2014/12/09 00:00 [revised]
PHST- 2014/12/18 00:00 [accepted]
PHST- 2015/01/20 06:00 [entrez]
PHST- 2015/01/20 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
AID - S0163-4453(15)00027-4 [pii]
AID - 10.1016/j.jinf.2014.12.020 [doi]
PST - ppublish
SO  - J Infect. 2015 Jun;70(6):659-67. doi: 10.1016/j.jinf.2014.12.020. Epub 2015 Jan 
      15.