PMID- 25598393 OWN - NLM STAT- MEDLINE DCOM- 20151001 LR - 20211203 IS - 1472-765X (Electronic) IS - 0266-8254 (Linking) VI - 60 IP - 4 DP - 2015 Apr TI - Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent memory impairment in Fischer 344 rats. PG - 307-14 LID - 10.1111/lam.12393 [doi] AB - To understand the anti-inflammaging effect of lactic acid bacteria, we selected NF-kappaB activation-inhibitory Lactobacillus pentosus var. plantarum C29 and investigated its memory-enhancing and anti-inflammatory effects in aged Fischer 344 rats. C29 (2 x 10(9) CFU rat(-1) ), which was orally administered once a day (6 days per week) for 8 weeks, significantly restored age-reduced spontaneous alternation to 95.2% of that seen in young rats (P < 0.05). C29 treatment also shortened the escape latency on the 4th day to 53.8% of that seen in young rats (P < 0.05). Twenty hours after the last training session, C29 significantly increased the swimming time within the platform quadrant, which was shortened in the aged control rats. Oral administration of C29 restored age-reduced doublecortin (DCX) and brain-derived neurotrophic factor (BDNF) expression and cAMP response element binding protein (CREB) activation in aged rats. Treatment of aged rats with C29 suppressed the expression of p16, cyclooxygenase-2, and inducible nitric oxide synthase, as well as the activation of Akt, mTOR, and NF-kappaB in the hippocampus. These findings suggest that C29 ameliorates ageing-dependent memory impairment by inhibiting NF-kappaB signalling pathway, inducing DCX and BDNF expression and activating CREB. SIGNIFICANCE AND IMPACT OF THE STUDY: The anti-inflammatory Lactobacillus pentosus var. plantarum C29 had the memory-enhancing effect in aged Fischer 344 rats by restoring doublecortin and brain-derived neurotrophic factor expression and suppressing p16 expression and NF-kappaB activation in the brain. Therefore, C29 may be useful in ameliorating age-related degenerative dementia. CI - (c) 2015 The Society for Applied Microbiology. FAU - Jeong, J-J AU - Jeong JJ AD - Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea. FAU - Woo, J-Y AU - Woo JY FAU - Kim, K-A AU - Kim KA FAU - Han, M J AU - Han MJ FAU - Kim, D-H AU - Kim DH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150204 PL - England TA - Lett Appl Microbiol JT - Letters in applied microbiology JID - 8510094 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cyclin-Dependent Kinase Inhibitor p16) RN - 0 (Dcx protein, mouse) RN - 0 (Dcx protein, rat) RN - 0 (Doublecortin Domain Proteins) RN - 0 (Doublecortin Protein) RN - 0 (Microtubule-Associated Proteins) RN - 0 (NF-kappa B) RN - 0 (Neuropeptides) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type II) RN - EC 1.14.99.1 (Cyclooxygenase 2) RN - EC 2.3.1.48 (CREB-Binding Protein) RN - EC 2.3.1.48 (Crebbp protein, rat) RN - EC 2.7.1.1 (mTOR protein, rat) RN - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) RN - EC 2.7.11.1 (TOR Serine-Threonine Kinases) SB - IM MH - Aging/metabolism MH - Animals MH - Anti-Inflammatory Agents/metabolism MH - Brain-Derived Neurotrophic Factor/*biosynthesis/metabolism MH - CREB-Binding Protein/biosynthesis/*metabolism MH - Cyclin-Dependent Kinase Inhibitor p16/biosynthesis MH - Cyclooxygenase 2/biosynthesis MH - Dementia/pathology/therapy MH - Doublecortin Domain Proteins MH - Doublecortin Protein MH - Enzyme Activation MH - Hippocampus/metabolism MH - Lactobacillus plantarum/*metabolism MH - Male MH - Maze Learning/physiology MH - Memory/physiology MH - Memory Disorders/*metabolism/therapy MH - Mice MH - Mice, Inbred C57BL MH - Microtubule-Associated Proteins/*biosynthesis/metabolism MH - NF-kappa B/antagonists & inhibitors/metabolism MH - Neuropeptides/*biosynthesis/metabolism MH - Nitric Oxide Synthase Type II/biosynthesis MH - Proto-Oncogene Proteins c-akt/metabolism MH - Rats MH - Rats, Inbred F344 MH - Signal Transduction MH - TOR Serine-Threonine Kinases/metabolism OTO - NOTNLM OT - Lactobacillus pentosus var. plantarum OT - ageing OT - inflammaging OT - memory EDAT- 2015/01/20 06:00 MHDA- 2015/10/02 06:00 CRDT- 2015/01/20 06:00 PHST- 2014/09/19 00:00 [received] PHST- 2015/01/08 00:00 [revised] PHST- 2015/01/08 00:00 [accepted] PHST- 2015/01/20 06:00 [entrez] PHST- 2015/01/20 06:00 [pubmed] PHST- 2015/10/02 06:00 [medline] AID - 10.1111/lam.12393 [doi] PST - ppublish SO - Lett Appl Microbiol. 2015 Apr;60(4):307-14. doi: 10.1111/lam.12393. Epub 2015 Feb 4.