PMID- 25598522
OWN - NLM
STAT- MEDLINE
DCOM- 20151231
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 36
IP  - 5
DP  - 2015 May
TI  - Genetic contribution of catechol-O-methyltransferase in hippocampal structural 
      and functional changes of female migraine sufferers.
PG  - 1782-95
LID - 10.1002/hbm.22737 [doi]
AB  - Physiological and emotional stressors are associated with or provoke each 
      migraine attack and cause structural and functional changes in the central 
      nervous system. The hippocampus, a limbic structure important in anxiety-related 
      behavior, is vulnerable to long-term stress. Given that 
      catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and 
      its genetic variation is thought to contribute to the interindividual variability 
      in pain perception and anxiety regulation, whether or not migraine and COMT 
      val(158) met genotype have an interactive effect in the key brain area related to 
      maladaptive stress, the hippocampus, is still poorly understood. Using 
      T1-weighted and resting functional MRI, we evaluated the effect of COMT genetic 
      variations on migraine and possible interactions between COMT and the disease in 
      brain structure and function in 135 females with migraine without aura (MWoA) and 
      111 matched health controls (HC). Optimized voxel-based morphometry (VBM) and 
      functional connectivity (FC) analyses were applied. From the whole brain VBM 
      analysis, we found a significant disease x genotype interaction in the 
      hippocampus, which overlapped with disease-related increase of gray matter (GM) 
      in val homozygote migraineurs. In our results, increased GM in the hippocampus 
      was only found in val homozygote MWoA compared to val homozygote HC. Moreover, FC 
      between the hippocampus and the medial prefrontal cortex was significantly 
      decreased in val homozygotes, and it was negatively correlated with self-rating 
      anxiety scale values.Our results indicated that brain structure and function of 
      the hippocampus are differentially affected by migraine in val homozygotes 
      compared with met carriers.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Liu, Jixin
AU  - Liu J
AD  - School of Life Science and Technology, Xidian University, Xi'an, People's 
      Republic of China.
FAU - Lan, Lei
AU  - Lan L
FAU - Mu, Junya
AU  - Mu J
FAU - Zhao, Ling
AU  - Zhao L
FAU - Yuan, Kai
AU  - Yuan K
FAU - Zhang, Yi
AU  - Zhang Y
FAU - Huang, Liyu
AU  - Huang L
FAU - Liang, Fanrong
AU  - Liang F
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150119
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Anxiety/pathology/physiopathology
MH  - Brain Mapping
MH  - Catechol O-Methyltransferase/*genetics
MH  - Female
MH  - Genotype
MH  - Genotyping Techniques
MH  - Gray Matter/pathology/physiopathology
MH  - Heterozygote
MH  - Hippocampus/*pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Migraine without Aura/*pathology/*physiopathology/psychology
MH  - Neural Pathways/pathology/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - Psychophysics
MH  - Rest
MH  - Young Adult
PMC - PMC6869255
OTO - NOTNLM
OT  - catechol-O-methyltransferase
OT  - functional connectivity
OT  - hippocampus
OT  - migraine
OT  - structural change
EDAT- 2015/01/20 06:00
MHDA- 2016/01/01 06:00
PMCR- 2015/01/19
CRDT- 2015/01/20 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2014/12/16 00:00 [revised]
PHST- 2015/01/02 00:00 [accepted]
PHST- 2015/01/20 06:00 [entrez]
PHST- 2015/01/20 06:00 [pubmed]
PHST- 2016/01/01 06:00 [medline]
PHST- 2015/01/19 00:00 [pmc-release]
AID - HBM22737 [pii]
AID - 10.1002/hbm.22737 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2015 May;36(5):1782-95. doi: 10.1002/hbm.22737. Epub 2015 Jan 19.