PMID- 25598680
OWN - NLM
STAT- MEDLINE
DCOM- 20150630
LR  - 20181202
IS  - 2005-8330 (Electronic)
IS  - 1229-6929 (Print)
IS  - 1229-6929 (Linking)
VI  - 16
IP  - 1
DP  - 2015 Jan-Feb
TI  - Transarterial chemoembolization using gelatin sponges or microspheres plus 
      lipiodol-doxorubicin versus doxorubicin-loaded beads for the treatment of 
      hepatocellular carcinoma.
PG  - 125-32
LID - 10.3348/kjr.2015.16.1.125 [doi]
AB  - OBJECTIVE: To retrospectively compare treatment of hepatocellular carcinoma (HCC) 
      with transarterial chemoembolization (TACE) using gelatin sponges or microspheres 
      plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). 
      MATERIALS AND METHODS: A total of 158 patients with HCC received TACE from 
      November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) 
      received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) 
      received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 
      (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and 
      adverse events (AEs) were evaluated. RESULTS: No significant difference was found 
      at baseline among the three groups. The doxorubicin dosage in group C was 
      significantly (p < 0.001) higher compared to the dose used in groups A or B 
      (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in 
      group C achieved complete response compared to those in groups A or B (32.1% vs. 
      6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive 
      disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs 
      were more common in groups A and B compared to group C, with rates of 54.7%, 
      34.1%, and 5.7%, respectively. CONCLUSION: In patients with HCC, TACE with DEB 
      offers better safety and efficacy profiles compared to either TACE with gelatin 
      sponges or TACE with microspheres.
FAU - Liu, Yi-Sheng
AU  - Liu YS
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C. ; Liver Cancer Collaborative Oncology Group, National 
      Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
FAU - Ou, Ming-Ching
AU  - Ou MC
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C.
FAU - Tsai, Yi-Shan
AU  - Tsai YS
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C.
FAU - Lin, Xi-Zhang
AU  - Lin XZ
AD  - Liver Cancer Collaborative Oncology Group, National Cheng-Kung University 
      Hospital, Tainan 704, Taiwan, R.O.C. ; Department of Internal Medicine, National 
      Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
FAU - Wang, Chien-Kuo
AU  - Wang CK
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C.
FAU - Tsai, Hong-Ming
AU  - Tsai HM
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C. ; Liver Cancer Collaborative Oncology Group, National 
      Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
FAU - Chuang, Ming-Tsung
AU  - Chuang MT
AD  - Department of Diagnostic Radiology, National Cheng-Kung University Hospital, 
      Tainan 704, Taiwan, R.O.C.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150109
PL  - Korea (South)
TA  - Korean J Radiol
JT  - Korean journal of radiology
JID - 100956096
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Drug Carriers)
RN  - 8008-53-5 (Ethiodized Oil)
RN  - 80168379AG (Doxorubicin)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Abdominal Pain/etiology
MH  - Adult
MH  - Aged
MH  - Antibiotics, Antineoplastic/*administration & dosage/adverse effects
MH  - Carcinoma, Hepatocellular/*drug therapy/mortality
MH  - Chemoembolization, Therapeutic
MH  - Disease-Free Survival
MH  - Doxorubicin/*administration & dosage/adverse effects
MH  - Drug Carriers/*chemistry
MH  - Ethiodized Oil/chemistry
MH  - Female
MH  - Fever/etiology
MH  - Follow-Up Studies
MH  - Gelatin/chemistry
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Liver Neoplasms/*drug therapy/mortality
MH  - Male
MH  - Microspheres
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC4296259
OTO - NOTNLM
OT  - Chemoembolization
OT  - Doxorubicin
OT  - Drug-eluting bead
OT  - Hepatocellular carcinoma
OT  - Microsphere
EDAT- 2015/01/20 06:00
MHDA- 2015/07/01 06:00
PMCR- 2015/01/01
CRDT- 2015/01/20 06:00
PHST- 2014/03/28 00:00 [received]
PHST- 2014/09/25 00:00 [accepted]
PHST- 2015/01/20 06:00 [entrez]
PHST- 2015/01/20 06:00 [pubmed]
PHST- 2015/07/01 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3348/kjr.2015.16.1.125 [doi]
PST - ppublish
SO  - Korean J Radiol. 2015 Jan-Feb;16(1):125-32. doi: 10.3348/kjr.2015.16.1.125. Epub 
      2015 Jan 9.