PMID- 25600245
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20191210
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 92
DP  - 2015 May
TI  - Intravenous self-administration of mephedrone, methylone and MDMA in female rats.
PG  - 90-7
LID - S0028-3908(15)00010-6 [pii]
LID - 10.1016/j.neuropharm.2015.01.003 [doi]
AB  - Male rats will intravenously self-administer (IVSA) the substituted cathinone 
      stimulants ("bath salts") mephedrone (4-methylmethcathione) and methylone 
      (3,4-methylenedioxymethcathinone) robustly, whereas the IVSA of 
      3,4-methylenedioxymethamphetamine (MDMA) is inconsistent in many rat models. 
      There are no data available on the self-administration of these drugs in female 
      rats, thus a study was undertaken to contrast them directly. Groups of female 
      Wistar rats were trained to self-administer mephedrone, methylone or MDMA (0.5 
      mg/kg/inf) under a Fixed-Ratio (FR) 1 schedule of reinforcement for 14 sessions. 
      Following the acquisition interval, animals were evaluated in FR (0.0, 0.125, 
      0.25, 0.5, 1.0, 2.5 mg/kg/inf) and PR (0.125, 1.0 mg/kg/inf) dose-substitution 
      procedures. The results show that female rats acquired the self-administration of 
      all three compounds with intakes in mephedrone-trained rats that were 
      significantly higher than that of methylone-trained or MDMA-trained rats. In 
      dose-substitution under either FR or PR contingencies, however, the potencies of 
      all three drugs were similar within the original training groups. The 
      mephedrone-trained animals exhibited higher intakes of all drugs during 
      dose-substitution, indicating lasting consequences of the training drug. Abuse 
      liability of these three compounds is therefore predicted to be similar in 
      established stimulant users but may differ in liability if they are primary drugs 
      of initiation.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Creehan, Kevin M
AU  - Creehan KM
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, CA, USA.
FAU - Vandewater, Sophia A
AU  - Vandewater SA
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, CA, USA.
FAU - Taffe, Michael A
AU  - Taffe MA
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, CA, USA. Electronic address: mtaffe@scripps.edu.
LA  - eng
GR  - R01 DA024105/DA/NIDA NIH HHS/United States
GR  - R01 DA024705/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150117
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - L4I4B1R01F (methylone)
SB  - IM
MH  - Administration, Intravenous
MH  - Animals
MH  - Central Nervous System Stimulants/*administration & dosage
MH  - Conditioning, Operant/*drug effects
MH  - Discrimination, Psychological/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hallucinogens/*pharmacology
MH  - Methamphetamine/administration & dosage/*analogs & derivatives
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Reinforcement Schedule
MH  - Self Administration
MH  - Time Factors
PMC - PMC4346510
MID - NIHMS656858
OTO - NOTNLM
OT  - 3,4-methylenedioxymethamphetamine (PubChem CID:1615)
OT  - 4-methylmethcathinone (PubChemCID: 45266826)
OT  - Bath salts
OT  - Drug addiction
OT  - Ecstasy
OT  - Reward
OT  - Substance abuse
OT  - methylone (PubChem CID: 45789647)
EDAT- 2015/01/21 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/05/01
CRDT- 2015/01/21 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2015/01/06 00:00 [revised]
PHST- 2015/01/07 00:00 [accepted]
PHST- 2015/01/21 06:00 [entrez]
PHST- 2015/01/21 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - S0028-3908(15)00010-6 [pii]
AID - 10.1016/j.neuropharm.2015.01.003 [doi]
PST - ppublish
SO  - Neuropharmacology. 2015 May;92:90-7. doi: 10.1016/j.neuropharm.2015.01.003. Epub 
      2015 Jan 17.