PMID- 25600616
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20181202
IS  - 1879-1336 (Electronic)
IS  - 1054-8807 (Linking)
VI  - 24
IP  - 4
DP  - 2015 Jul-Aug
TI  - Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the 
      PPARgamma/LXRalpha signaling pathway in THP-1 macrophage-derived foam cells.
PG  - 230-5
LID - S1054-8807(14)00163-X [pii]
LID - 10.1016/j.carpath.2014.12.004 [doi]
AB  - BACKGROUND: ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette 
      transporter G1 (ABCG1), and scavenger receptor-B1 (SR-B1) promote cholesterol 
      efflux from cells to lipid-poor apolipoprotein A-I and play an important role in 
      the development of atherosclerosis. Liver X receptor (LXRalpha) and peroxisome 
      proliferator-activated receptor-gamma (PPARgamma) operate as cholesterol sensors, 
      which may protect from cholesterol overload by stimulating cholesterol efflux 
      from cells to high-density lipoprotein through ABCA1, ABCG1, and SR-B1. Propofol 
      administration is associated with cardiovascular protective effects, including 
      anti-inflammatory and antioxidant properties. Here, we examined the effect of 
      propofol on ABCA1, ABCG1, and SR-B1 expression and explored whether PPARgamma and 
      LXRalpha were involved in the regulation of propofol-induced ABCA1, ABCG1, and SR-B1 
      expression in THP-1 macrophage-derived foam cells. METHODS AND RESULTS: Propofol 
      significantly increased expression levels of ABCA1, ABCG1, and SR-B1 in a 
      time-dependent manner. Cellular cholesterol content was decreased while 
      cholesterol efflux was increased by propofol treatment. Moreover, PPARgamma and LXRalpha 
      were up-regulated by propofol treatment. In addition, the up-regulated expression 
      of ABCA1, ABCG1, and SR-B1 by propofol was significantly abolished by both PPARgamma 
      siRNA and LXRalpha siRNA in THP-1 macrophage-derived foam cells. CONCLUSION: These 
      results provide evidence that propofol up-regulates expression of ABCA1, ABCG1, 
      and SR-B1 through the PPARgamma/LXRalpha pathway in THP-1 macrophage-derived foam cells.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Ma, Xin
AU  - Ma X
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Li, Shu-Fen
AU  - Li SF
AD  - Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Qin, Zai-Sheng
AU  - Qin ZS
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Ye, Jing
AU  - Ye J
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Zhao, Zhen-Long
AU  - Zhao ZL
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Fang, Hai-Hong
AU  - Fang HH
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Yao, Zhi-Wen
AU  - Yao ZW
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Gu, Miao-Ning
AU  - Gu MN
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Hu, Yan-Wei
AU  - Hu YW
AD  - Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China. Electronic address: ywhu0618@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141227
PL  - United States
TA  - Cardiovasc Pathol
JT  - Cardiovascular pathology : the official journal of the Society for Cardiovascular 
      Pathology
JID - 9212060
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Liver X Receptors)
RN  - 0 (NR1H3 protein, human)
RN  - 0 (Orphan Nuclear Receptors)
RN  - 0 (PPAR gamma)
RN  - 0 (RNA, Messenger)
RN  - 0 (SCARB1 protein, human)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/genetics/*metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/genetics/*metabolism
MH  - Anticholesteremic Agents/*pharmacology
MH  - Cell Line
MH  - Cholesterol/metabolism
MH  - Foam Cells/*drug effects/metabolism
MH  - Humans
MH  - Liver X Receptors
MH  - Orphan Nuclear Receptors/genetics/*metabolism
MH  - PPAR gamma/genetics/*metabolism
MH  - Propofol/*pharmacology
MH  - RNA Interference
MH  - RNA, Messenger/metabolism
MH  - Scavenger Receptors, Class B/genetics/*metabolism
MH  - Signal Transduction/*drug effects
MH  - Time Factors
MH  - Transfection
MH  - Up-Regulation
OTO - NOTNLM
OT  - ABCA1
OT  - Cholesterol efflux
OT  - Macrophage
OT  - PPARgamma/LXRalpha signaling pathway
OT  - Propofol
EDAT- 2015/01/21 06:00
MHDA- 2016/03/05 06:00
CRDT- 2015/01/21 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2014/12/02 00:00 [revised]
PHST- 2014/12/19 00:00 [accepted]
PHST- 2015/01/21 06:00 [entrez]
PHST- 2015/01/21 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
AID - S1054-8807(14)00163-X [pii]
AID - 10.1016/j.carpath.2014.12.004 [doi]
PST - ppublish
SO  - Cardiovasc Pathol. 2015 Jul-Aug;24(4):230-5. doi: 10.1016/j.carpath.2014.12.004. 
      Epub 2014 Dec 27.