PMID- 25600701
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20171116
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 29
IP  - 3
DP  - 2015 Apr
TI  - Glucosepane and oxidative markers in skin collagen correlate with intima media 
      thickness and arterial stiffness in long-term type 1 diabetes.
PG  - 407-12
LID - S1056-8727(14)00408-5 [pii]
LID - 10.1016/j.jdiacomp.2014.12.011 [doi]
AB  - AIMS: To study intima media thickness (cIMT) and arterial stiffness in type 1 
      diabetes of long duration, and their associations with the collagen cross-linker 
      glucosepane and inflammatory and oxidative markers. METHODS: Twenty-seven 
      individuals with type 1 diabetes mellitus of 40 years duration from the Oslo 
      Study cohort and 24 age-matched controls were included. cIMT measurements of the 
      carotid artery were performed longitudinally. Pulse wave velocity (PWV), 
      augmentation index (AIx) and augmentation pressure (AP) were assessed 
      cross-sectionally. Glucosepane and the oxidative product methionine sulfoxide 
      (MetSO) were determined in skin collagen by liquid chromatography-mass 
      spectrometry. Circulating inflammatory markers were determined by ELISAs. 
      RESULTS: The diabetes patients had significantly increased cIMT and arterial 
      stiffness compared to controls. Significant correlations were noted for skin 
      glucosepane with cIMT (r=0.41) and PWV (r=0.44). Skin MetSO and monocyte 
      chemoattractant protein-1 (MCP-1) correlated significantly with AIx and AP. After 
      correcting for age and mean arterial pressure in multiple linear regression 
      analysis, MetSO and MCP-1 were both independently associated with AIx and AP. 
      CONCLUSIONS: These results suggest more premature atherosclerosis and arterial 
      pathology in individuals with diabetes compared to age-matched controls. They 
      also suggest an association between the arterial pathology and markers of 
      collagen crosslinking, oxidative damage and inflammation in type 1 diabetes 
      patients of forty years disease duration.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Sveen, Kari Anne
AU  - Sveen KA
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of 
      Medicine University of Oslo, Oslo, Norway. Electronic address: 
      k.a.sveen@medisin.uio.no.
FAU - Dahl-Jorgensen, Knut
AU  - Dahl-Jorgensen K
AD  - Department of Pediatrics, Oslo University Hospital, Ullevaal, Oslo, Norway; 
      Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, 
      Norway.
FAU - Stensaeth, Knut Haakon
AU  - Stensaeth KH
AD  - Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, 
      Norway.
FAU - Angel, Kristin
AU  - Angel K
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway.
FAU - Seljeflot, Ingebjorg
AU  - Seljeflot I
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway; Center for 
      Clinical Heart Research, Oslo University hospital, Ullevaal, Oslo, Norway; 
      Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, 
      Norway.
FAU - Sell, David R
AU  - Sell DR
AD  - Departments of Pathology and Biochemistry Case Western Reserve University, 
      Cleveland, OH, USA.
FAU - Monnier, Vincent M
AU  - Monnier VM
AD  - Departments of Pathology and Biochemistry Case Western Reserve University, 
      Cleveland, OH, USA.
FAU - Hanssen, Kristian F
AU  - Hanssen KF
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of 
      Medicine University of Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20141229
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Glycation End Products, Advanced)
RN  - 66K23JT22H (glucosepane)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/analysis/*metabolism
MH  - Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Collagen/chemistry/*metabolism
MH  - Diabetes Mellitus, Type 1/complications/diagnostic 
      imaging/*metabolism/*physiopathology
MH  - Diabetic Angiopathies/complications/diagnostic imaging/metabolism/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycation End Products, Advanced/analysis/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Skin/chemistry/*metabolism
MH  - Vascular Stiffness
MH  - Young Adult
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Diabetes mellitus
OT  - Glucosepane
OT  - Methionine sulfoxide
OT  - Type 1
EDAT- 2015/01/21 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/01/21 06:00
PHST- 2014/10/17 00:00 [received]
PHST- 2014/12/20 00:00 [revised]
PHST- 2014/12/20 00:00 [accepted]
PHST- 2015/01/21 06:00 [entrez]
PHST- 2015/01/21 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S1056-8727(14)00408-5 [pii]
AID - 10.1016/j.jdiacomp.2014.12.011 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2015 Apr;29(3):407-12. doi: 
      10.1016/j.jdiacomp.2014.12.011. Epub 2014 Dec 29.