PMID- 25601533 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20220409 IS - 1549-4713 (Electronic) IS - 0161-6420 (Print) IS - 0161-6420 (Linking) VI - 122 IP - 5 DP - 2015 May TI - Multimodal characterization of proliferative diabetic retinopathy reveals alterations in outer retinal function and structure. PG - 957-67 LID - S0161-6420(14)01128-2 [pii] LID - 10.1016/j.ophtha.2014.12.001 [doi] AB - PURPOSE: To identify changes in retinal function and structure in persons with proliferative diabetic retinopathy (PDR), including the effects of panretinal photocoagulation (PRP). DESIGN: Cross-sectional study. PARTICIPANTS: Thirty adults who underwent PRP for PDR, 15 adults with untreated PDR, and 15 age-matched controls. METHODS: Contrast sensitivity, frequency doubling perimetry (FDP), Humphrey visual fields, photostress recovery, and dark adaptation were assessed. Fundus photography and macular spectral-domain optical coherence tomography (SD OCT) were performed. To quantify retinal layer thicknesses, SD OCT scans were segmented semiautomatically. MAIN OUTCOME MEASURES: Visual function measures were compared among patients with PDR and PRP, untreated patients with PDR, and controls. Mean retinal layer thicknesses were compared between groups. Correlation analyses were performed to evaluate associations between visual function measures and retinal layer thicknesses. RESULTS: A significant reduction of FDP mean deviation (MD) was exhibited in PRP-treated patients with PDR (MD +/- standard deviation, -8.20+/-5.76 dB; P < 0.0001) and untreated patients (-5.48+/-4.48 dB; P < 0.0001) relative to controls (1.07+/-2.50 dB). Reduced log contrast sensitivity compared with controls (1.80+/-0.14) also was observed in both PRP-treated patients (1.42+/-0.17; P < 0.0001) and untreated patients (1.56+/-0.20; P = 0.001) with PDR. Compared with controls, patients treated with PRP demonstrated increased photostress recovery time (151.02+/-104.43 vs. 70.64+/-47.14 seconds; P = 0.001) and dark adaptation speed (12.80+/-5.15 vs. 9.74+/-2.56 minutes; P = 0.022). Patients who underwent PRP had diffusely thickened nerve fiber layers (P = 0.024) and diffusely thinned retinal pigment epithelium (RPE) layers (P = 0.009) versus controls. Untreated patients with PDR also had diffusely thinned RPE layers (P = 0.031) compared with controls. CONCLUSIONS: Patients with untreated PDR exhibited inner retinal dysfunction, as evidenced by reduced contrast sensitivity and FDP performance, accompanied by alterations in inner and outer retinal structure. Patients who underwent PRP had more profound changes in outer retinal structure and function. Distinguishing the effects of PDR and PRP may guide the development of restorative vision therapies for patients with advanced diabetic retinopathy. CI - Copyright (c) 2015 American Academy of Ophthalmology. All rights reserved. FAU - Boynton, Grace E AU - Boynton GE AD - Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. FAU - Stem, Maxwell S AU - Stem MS AD - Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. FAU - Kwark, Leon AU - Kwark L AD - Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. FAU - Jackson, Gregory R AU - Jackson GR AD - MacuLogix, Inc., Hummelstown, Pennsylvania. FAU - Farsiu, Sina AU - Farsiu S AD - Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Biomedical Engineering, Duke University, Durham, North Carolina. FAU - Gardner, Thomas W AU - Gardner TW AD - Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. Electronic address: tomwgard@umich.edu. LA - eng GR - DP3 DK094292/DK/NIDDK NIH HHS/United States GR - P30 DK020572/DK/NIDDK NIH HHS/United States GR - R01 EY020582/EY/NEI NIH HHS/United States GR - R01 EY022691/EY/NEI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150117 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM MH - Contrast Sensitivity/physiology MH - Cross-Sectional Studies MH - Dark Adaptation MH - Diabetes Mellitus, Type 1/complications MH - Diabetes Mellitus, Type 2/complications MH - Diabetic Retinopathy/*diagnosis/physiopathology/surgery MH - Female MH - Humans MH - Laser Coagulation MH - Male MH - Middle Aged MH - Multimodal Imaging MH - Retina/*physiopathology MH - Retinal Neovascularization/*diagnosis/physiopathology/surgery MH - Tomography, Optical Coherence MH - Visual Acuity/physiology MH - Visual Field Tests MH - Visual Fields/physiology PMC - PMC4414692 MID - NIHMS648153 EDAT- 2015/01/21 06:00 MHDA- 2015/07/17 06:00 PMCR- 2016/05/01 CRDT- 2015/01/21 06:00 PHST- 2014/04/30 00:00 [received] PHST- 2014/11/21 00:00 [revised] PHST- 2014/12/03 00:00 [accepted] PHST- 2015/01/21 06:00 [entrez] PHST- 2015/01/21 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] PHST- 2016/05/01 00:00 [pmc-release] AID - S0161-6420(14)01128-2 [pii] AID - 10.1016/j.ophtha.2014.12.001 [doi] PST - ppublish SO - Ophthalmology. 2015 May;122(5):957-67. doi: 10.1016/j.ophtha.2014.12.001. Epub 2015 Jan 17.