PMID- 25601573
OWN - NLM
STAT- MEDLINE
DCOM- 20151202
LR  - 20150304
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 283
DP  - 2015 Apr 15
TI  - Age dependent levels of plasma homocysteine and cognitive performance.
PG  - 139-44
LID - S0166-4328(15)00020-0 [pii]
LID - 10.1016/j.bbr.2015.01.016 [doi]
AB  - Elevated plasma homocysteine (hcy) levels, also known as hyperhomocysteinemia 
      (hhcy), have been associated with cognitive impairment and neurodegenerative 
      disorders. Hhcy has been attributed to deficiency of B vitamins which can 
      adversely affect the brain and result in memory loss and poor attention power. 
      Monitoring hcy levels and the use of vitamin supplementation to treat hhcy may 
      therefore prove advantageous for the prevention and management of cognitive 
      impairment. With this in consideration, we measured plasma hcy, folate and 
      vitamin B12 levels in 639 subjects from different age groups in two sub-regions 
      of India. Cognitive function was also measured using attention span and immediate 
      and delayed memory recall tests. Depression scores were obtained using the Beck 
      Depression Inventory-II and functional impairment was assessed using the 
      functional activities questionnaire (FAQ) score. As hhcy has also been linked to 
      inflammation, plasma levels of high sensitivity C-reactive protein (hsCRP) and 
      interleukin-6 (IL-6) were also measured. The results demonstrated significant 
      negative correlations between hcy levels and folic acid levels, vitamin B12 
      levels and cognitive performance (attention span and delayed but not immediate 
      memory recall) along with significant positive correlations between hcy levels 
      and depression scores and hsCRP (but not IL-6) levels. A positive correlation was 
      also observed between hcy levels and FAQ scores, however this was not found to be 
      significant. Based on these results, folic acid and vitamin B12 intervention in 
      people with elevated hcy levels in India could prove to be effective in lowering 
      hcy levels and help maintain or improve cognitive function.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Agrawal, Aruna
AU  - Agrawal A
AD  - Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
FAU - Ilango, K
AU  - Ilango K
AD  - Interdisciplinary School of Indian System of Medicine, SRM University, 
      Katankulathur, Chennai, India.
FAU - Singh, Praveen K
AU  - Singh PK
AD  - Arvind Remedies Ltd., Chennai, India.
FAU - Karmakar, Dipankar
AU  - Karmakar D
AD  - Arvind Remedies Ltd., Chennai, India.
FAU - Singh, G P I
AU  - Singh GP
AD  - Adesh University, Barnala Road, Bathinda, Punjab, India.
FAU - Kumari, Rinki
AU  - Kumari R
AD  - Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; 
      Interdisciplinary School of Indian System of Medicine, SRM University, 
      Katankulathur, Chennai, India; Arvind Remedies Ltd., Chennai, India; Adesh 
      University, Barnala Road, Bathinda, Punjab, India. Electronic address: 
      rinkiv3@gmail.com.
FAU - Dubey, G P
AU  - Dubey GP
AD  - Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150116
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*blood/*psychology
MH  - Attention/physiology
MH  - C-Reactive Protein/metabolism
MH  - Cognition/*physiology
MH  - Depression/blood
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - India
MH  - Interleukin-6/blood
MH  - Male
MH  - Mental Recall/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
MH  - Vitamin B 12/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Cognition
OT  - Folate
OT  - Homocysteine
OT  - Interleukin-6
OT  - Vitamin B12
EDAT- 2015/01/21 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/21 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2015/01/07 00:00 [revised]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/01/21 06:00 [entrez]
PHST- 2015/01/21 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0166-4328(15)00020-0 [pii]
AID - 10.1016/j.bbr.2015.01.016 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Apr 15;283:139-44. doi: 10.1016/j.bbr.2015.01.016. Epub 
      2015 Jan 16.