PMID- 25605161
OWN - NLM
STAT- MEDLINE
DCOM- 20151006
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 15
IP  - 24
DP  - 2014
TI  - Association between laryngeal squamous cell carcinoma and polymorphisms in tumor 
      necrosis factor related apoptosis induce ligand (TRAIL), TRAIL receptor and 
      sTRAIL levels.
PG  - 10697-703
AB  - The laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant 
      tumors occurring in the head and neck. Tumor necrosis factor related apoptosis 
      induce ligand (TRAIL) and TRAIL-receptors (DR4, DR5, DcR1, DcR2) are known as 
      important members of TRAIL-mediated biochemical signaling pathway. Associations 
      between polymorphisms in these genes and clinicopathological characteristics of 
      human laryngeal carcinoma are not well defined. This study therefore aimed to 
      investigate a possible relationship among the TRAIL and TRAIL-DR4 polymorphisms 
      and sTRAIL levels in the risk or progression of LSCC. A total of 99 patients with 
      laryngeal cancer and 120 healthy subjects were enrolled in the study. DR4 C626G 
      and TRAIL 1595 C/T genotypes were determined by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and sTRAIL 
      levels were measured by ELISA. There were significant differences in the 
      distribution of DR4 C626G genotypes and frequencies of the alleles between 
      laryngeal cancer patients and controls (p<0.001) but not in TRAIL 1595 C/T. We 
      found the increased frequency of the DR4 C626G homozygote CC genotype in patients 
      than in controls (p<0.001). Haplotype analysis revealed that there was also a 
      statistically significant relationship between TRAIL and TRAIL-DR4 polymorphisms 
      and laryngeal cancer. Serum sTRAIL levels in the laryngeal patients with CC 
      genotype who had advanced tumour stage were lower than those of patients with 
      early tumor stage (p=0.014). Our findings suggest that DR4 C626G genotypes and 
      sTRAIL levels might be associated with progression of laryngeal cancer in the 
      Turkish population.
FAU - Verim, Aysegul
AU  - Verim A
AD  - Department of Otorhinolaryngology/Head and Neck Surgery, Haydarpasa Numune 
      Education and Research Hospital, Istanbul, Turkey E-mail : ilhanyaylim@gmail.com.
FAU - Turan, Saime
AU  - Turan S
FAU - Farooqi, Ammad Ahmad
AU  - Farooqi AA
FAU - Kahraman, Ozlem Timirci
AU  - Kahraman OT
FAU - Tepe-Karaca, Cigdem
AU  - Tepe-Karaca C
FAU - Yildiz, Yemliha
AU  - Yildiz Y
FAU - Naiboglu, Baris
AU  - Naiboglu B
FAU - Ozkan, Nazli Ezgi
AU  - Ozkan NE
FAU - Ergen, Arzu
AU  - Ergen A
FAU - Isitmangil, Gulbu Aydinoglu
AU  - Isitmangil GA
FAU - Yaylim, Ilhan
AU  - Yaylim I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
SB  - IM
MH  - Adolescent
MH  - Carcinoma, Squamous Cell/blood/*genetics/secondary
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/blood/*genetics/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/blood/*genetics/pathology
MH  - Neoplasm Staging
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Prognosis
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand/*genetics
MH  - TNF-Related Apoptosis-Inducing Ligand/*blood/*genetics
EDAT- 2015/01/22 06:00
MHDA- 2015/10/07 06:00
CRDT- 2015/01/22 06:00
PHST- 2015/01/22 06:00 [entrez]
PHST- 2015/01/22 06:00 [pubmed]
PHST- 2015/10/07 06:00 [medline]
AID - 10.7314/apjcp.2014.15.24.10697 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2014;15(24):10697-703. doi: 
      10.7314/apjcp.2014.15.24.10697.