PMID- 25605345 OWN - NLM STAT- MEDLINE DCOM- 20150921 LR - 20181113 IS - 1748-880X (Electronic) IS - 0007-1285 (Print) IS - 0007-1285 (Linking) VI - 88 IP - 1048 DP - 2015 Apr TI - Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. PG - 20140612 LID - 10.1259/bjr.20140612 [doi] LID - 20140612 AB - OBJECTIVE: Synchronous malignancy in both breasts is a rare incidence. The present study aims at dosimetric comparison of conventional bitangential radiotherapy (RT) technique with conventional [field-in-field (FIF)] and rotational [Helical TomoTherapy((R)) and TomoDirect (TD); Accuray Inc., Sunnyvale, CA] intensity-modulated RT for patients with synchronous bilateral breast cancer (SBBC). METHODS: CT data sets of 10 patients with SBBC were selected for the present study. RT was planned for all patients on both sides to whole breast and/or chest wall using the above-mentioned techniques. Six females with breast conservation on at least one side also had a composite plan along with tumour bed (TB) boost using sequential electrons for bitangential and FIF techniques or sequential helical tomotherapy (HT) boost (for TD) or simultaneous integrated boost (SIB) for HT. RESULTS: All techniques produced acceptable target coverage. The hotspot was significantly lower with FIF technique and HT but higher with TD. For the organs at risk doses, HT resulted in significant reduction of the higher dose volumes. Similarly, TD resulted in significant reduction of the mean dose to the heart and total lung by reducing the lower dose volumes. All techniques of delivering boost to the TB were comparable in terms of target coverage. HT-SIB markedly reduced mean doses to the total lung and heart by specifically lowering the higher dose volumes. CONCLUSION: This study demonstrates the cardiac and pulmonary sparing ability of tomotherapy in the setting of SBBC. ADVANCES IN KNOWLEDGE: This is the first study demonstrating feasibility of treatment of SBBC using tomotherapy. FAU - Wadasadawala, T AU - Wadasadawala T AD - 1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. FAU - Visariya, B AU - Visariya B FAU - Sarin, R AU - Sarin R FAU - Upreti, R R AU - Upreti RR FAU - Paul, S AU - Paul S FAU - Phurailatpam, R AU - Phurailatpam R LA - eng PT - Comparative Study PT - Journal Article DEP - 20150121 PL - England TA - Br J Radiol JT - The British journal of radiology JID - 0373125 SB - IM MH - Breast Neoplasms/pathology/*radiotherapy/surgery MH - Combined Modality Therapy MH - Female MH - Humans MH - Neoplasms, Multiple Primary/pathology/*radiotherapy MH - Organs at Risk MH - Pilot Projects MH - Radiotherapy Dosage MH - Radiotherapy Planning, Computer-Assisted MH - Radiotherapy, Intensity-Modulated/*methods MH - Treatment Outcome PMC - PMC4651259 EDAT- 2015/01/22 06:00 MHDA- 2015/09/22 06:00 PMCR- 2016/04/01 CRDT- 2015/01/22 06:00 PHST- 2015/01/22 06:00 [entrez] PHST- 2015/01/22 06:00 [pubmed] PHST- 2015/09/22 06:00 [medline] PHST- 2016/04/01 00:00 [pmc-release] AID - 10.1259/bjr.20140612 [doi] PST - ppublish SO - Br J Radiol. 2015 Apr;88(1048):20140612. doi: 10.1259/bjr.20140612. Epub 2015 Jan 21.