PMID- 25606057
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150121
LR  - 20201001
IS  - 1755-8166 (Print)
IS  - 1755-8166 (Electronic)
IS  - 1755-8166 (Linking)
VI  - 7
IP  - 1
DP  - 2014
TI  - TRIP11-PDGFRB fusion in a patient with a therapy-related myeloid neoplasm with 
      t(5;14)(q33;q32) after treatment for acute promyelocytic leukemia.
PG  - 103
LID - 10.1186/s13039-014-0103-6 [doi]
LID - 103
AB  - BACKGROUND: Therapy-related myeloid neoplasm after treatment for acute 
      promyelocytic leukemia (APL) is a relatively infrequent but severe complication. 
      Most therapy-related myeloid neoplasms after treatment for APL are classified as 
      therapy-related myelodysplastic syndrome or therapy-related acute myeloid 
      leukemia. Translocation of 5q31-33, PDGFRB occur rarely in therapy-related 
      myeloid neoplasm and there has been two identified PDGFRB partner genes located 
      at 14q32, TRIP11 and KIAA1509. RESULTS: The TRIP11-PDGFRB fusion was identified 
      in a patient with therapy-related myeloid neoplasm with t(5;14)(q33;q32) after 
      treatment of APL using conventional cytogenetics, fluorescence in situ 
      hybridization (FISH) and molecular methods. Cytogenetic analysis of the bone 
      marrow aspirate revealed 46, XY, t(5;14)(q33;q32) in all 20 analyzed cells. No 
      other cytogenetic abnormalities were observed. Break-apart FISH analysis 
      demonstrated that rearrangement of PDGFRB at 5q33 was positive in 460 of 500 
      cells analyzed, while the PML-RARA rearrangement remained undetectable by RT-PCR. 
      Sequencing of RT-PCR products revealed fusion between exon 16 of TRIP11 and exon 
      11 of PDGFRB. However, the KIAA1509-PDGFRB fusion was not detected by RT-PCR. 
      CONCLUSION: We firstly demonstrated that therapy-related myeloid neoplasm with 
      TRIP11-PDGFRB fusion was identified after treatment of APL.
FAU - Kim, Hoon-Gu
AU  - Kim HG
AD  - Departments of Internal Medicine, Gyeongsang National University School of 
      Medicine, 79 Gangnam-ro, Jinju, Korea.
FAU - Jang, Ja-Hyun
AU  - Jang JH
AD  - Green Cross Laboratories, Yongin, Korea.
FAU - Koh, Eun-Ha
AU  - Koh EH
AD  - Departments of Laboratory Medicine, Gyeongsang National University School of 
      Medicine, 79 Gangnam-ro, 660-702 Jinju, Korea ; Institute of Heath Sciences, 
      Gyeongsang National University School of Medicine, Jinju, Korea.
LA  - eng
PT  - Case Reports
DEP - 20141223
PL  - England
TA  - Mol Cytogenet
JT  - Molecular cytogenetics
JID - 101317942
PMC - PMC4299380
OTO - NOTNLM
OT  - Acute promyelocytic leukemia
OT  - PDGFRB
OT  - TRIP11
OT  - Therapy-related myeloid neoplasm
OT  - t(5;14)(q33;32)
EDAT- 2015/01/22 06:00
MHDA- 2015/01/22 06:01
PMCR- 2014/12/23
CRDT- 2015/01/22 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2014/12/15 00:00 [accepted]
PHST- 2015/01/22 06:00 [entrez]
PHST- 2015/01/22 06:00 [pubmed]
PHST- 2015/01/22 06:01 [medline]
PHST- 2014/12/23 00:00 [pmc-release]
AID - 103 [pii]
AID - 10.1186/s13039-014-0103-6 [doi]
PST - epublish
SO  - Mol Cytogenet. 2014 Dec 23;7(1):103. doi: 10.1186/s13039-014-0103-6. eCollection 
      2014.