PMID- 25606417
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150121
LR  - 20201001
IS  - 2214-5400 (Print)
IS  - 2214-5400 (Electronic)
IS  - 2214-5400 (Linking)
VI  - 2
DP  - 2014 Dec
TI  - Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes 
      mellitus in Asian population.
PG  - 332-41
LID - 10.1016/j.mgene.2014.04.006 [doi]
AB  - OBJECTIVE: To clarify the association of rs11196218 polymorphism in transcription 
      factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Asian population 
      by a case-control study and meta-analysis. METHODS: In the case-control study, 
      1842 patients with T2DM and 7777 normal glucose-tolerant controls in the Henan 
      province of China were genotyped for rs11196218 in TCF7L2 by PCR-ligase detection 
      reaction. We used allele, co-dominant, dominant and recessive models to evaluate 
      the risk association and performed a meta-analysis of the results of different 
      genetic models in previous studies and the current study. RESULTS: The AG 
      genotype of rs11196218 was associated with risk of T2DM in the Henan population 
      (odds ratio 1.37, 95% confidence interval 1.06-1.78), and dominant model showed 
      marginal significant association (1.28, 0.99-1.67). Meta-analysis of 10 studies 
      revealed the dominant model associated with T2DM in the overall population (1.20, 
      1.05-1.36). When stratified by region (southern and northern China and Japan), 
      both the AG genotype and the dominant model were associated with risk of T2DM in 
      southern Chinese (1.31, 1.03-1.66; 1.27, 1.01-1.60, respectively). CONCLUSION: 
      The rs11196218 polymorphism in TCF7L2 is associated with risk of T2DM in Asian 
      population.
FAU - Zhai, Yujia
AU  - Zhai Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Zhao, Jingzhi
AU  - Zhao J
AD  - Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of 
      China.
FAU - You, Haifei
AU  - You H
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Pang, Chao
AU  - Pang C
AD  - Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of 
      China.
FAU - Yin, Lei
AU  - Yin L
AD  - Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of 
      China.
FAU - Guo, Tan
AU  - Guo T
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Feng, Tianping
AU  - Feng T
AD  - Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of 
      China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Gao, Kaiping
AU  - Gao K
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Luo, Xinping
AU  - Luo X
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Wang, Jinjin
AU  - Wang J
AD  - Department of Traditional Chinese Medicine Prevention, Preventive Medicine 
      Research Evaluation Center, Henan University of Traditional Chinese Medicine, 
      Zhengzhou 450008, People's Republic of China.
FAU - Li, Linlin
AU  - Li L
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Wang, Bingyuan
AU  - Wang B
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Ren, Yongcheng
AU  - Ren Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou 450001, People's Republic of China.
FAU - Shen, Yanxia
AU  - Shen Y
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Zhu, Tian
AU  - Zhu T
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
FAU - Hu, Dongsheng
AU  - Hu D
AD  - Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20140504
PL  - Netherlands
TA  - Meta Gene
JT  - Meta gene
JID - 101627670
PMC - PMC4287822
OTO - NOTNLM
OT  - 95% CI, 95% confidence interval
OT  - MAF, minor allele frequency
OT  - OR, odds ratio
OT  - PARP, population-attributable risk proportion
OT  - PCR-LDR, polymerase chain reaction-ligase detection reaction
OT  - SNP, single nucleotide polymorphism
OT  - Single nucleotide polymorphism
OT  - T2DM, type 2 diabetes mellitus
OT  - TCF7L2
OT  - TCF7L2, factor 7-like 2 gene
OT  - Type 2 diabetes mellitus
OT  - rs11196218
EDAT- 2015/01/22 06:00
MHDA- 2015/01/22 06:01
PMCR- 2014/05/04
CRDT- 2015/01/22 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/03/16 00:00 [revised]
PHST- 2014/04/10 00:00 [accepted]
PHST- 2015/01/22 06:00 [entrez]
PHST- 2015/01/22 06:00 [pubmed]
PHST- 2015/01/22 06:01 [medline]
PHST- 2014/05/04 00:00 [pmc-release]
AID - S2214-5400(14)00025-5 [pii]
AID - 10.1016/j.mgene.2014.04.006 [doi]
PST - epublish
SO  - Meta Gene. 2014 May 4;2:332-41. doi: 10.1016/j.mgene.2014.04.006. eCollection 
      2014 Dec.