PMID- 25611571
OWN - NLM
STAT- MEDLINE
DCOM- 20151216
LR  - 20181113
IS  - 1933-6926 (Electronic)
IS  - 1933-6918 (Print)
IS  - 1933-6918 (Linking)
VI  - 9
IP  - 1-2
DP  - 2015
TI  - Spatial organization of the tenascin-C microenvironment in experimental and human 
      cancer.
PG  - 4-13
LID - 10.1080/19336918.2015.1005452 [doi]
AB  - The extracellular matrix (ECM) molecule tenascin-C (TNC) promotes tumor 
      progression. This has recently been demonstrated in the stochastic murine 
      RIP1-Tag2 insulinoma model, engineered to either express TNC abundantly or to be 
      devoid of TNC. However, our knowledge about organization of the TNC 
      microenvironment is scant. Here we determined the spatial distribution of TNC 
      together with other ECM molecules in murine RIP1-Tag2 insulinoma and human cancer 
      tissue (insulinoma and colorectal carcinoma). We found that TNC is organized in 
      matrix tracks together with other ECM molecules of the AngioMatrix signature, a 
      previously described gene expression profile that characterizes the angiogenic 
      switch. Moreover, stromal cells including endothelial cells, fibroblasts and 
      leukocytes were enriched in the TNC tracks. Thus, TNC tracks may provide niches 
      for stromal cells and regulate their behavior. Given similarities of TNC rich 
      niches for stromal cells in human insulinoma and colon cancer, we propose that 
      the RIP1-Tag2 model may be useful for providing insights into the contribution of 
      the tumor stroma specific ECM as promoter of cancer progression.
FAU - Spenle, Caroline
AU  - Spenle C
AD  - a Inserm U1109 ; The Microenvironmental Niche in Tumorigenesis and Targeted 
      Therapy ; (MN3T) ; Strasbourg , France.
FAU - Gasser, Isabelle
AU  - Gasser I
FAU - Saupe, Falk
AU  - Saupe F
FAU - Janssen, Klaus-Peter
AU  - Janssen KP
FAU - Arnold, Christiane
AU  - Arnold C
FAU - Klein, Annick
AU  - Klein A
FAU - van der Heyden, Michael
AU  - van der Heyden M
FAU - Mutterer, Jerome
AU  - Mutterer J
FAU - Neuville-Mechine, Agnes
AU  - Neuville-Mechine A
FAU - Chenard, Marie-Pierre
AU  - Chenard MP
FAU - Guenot, Dominique
AU  - Guenot D
FAU - Esposito, Irene
AU  - Esposito I
FAU - Slotta-Huspenina, Julia
AU  - Slotta-Huspenina J
FAU - Ambartsumian, Noona
AU  - Ambartsumian N
FAU - Simon-Assmann, Patricia
AU  - Simon-Assmann P
FAU - Orend, Gertraud
AU  - Orend G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Adh Migr
JT  - Cell adhesion & migration
JID - 101469464
RN  - 0 (Tenascin)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Movement/*physiology
MH  - Colorectal Neoplasms/*metabolism
MH  - Disease Models, Animal
MH  - Extracellular Matrix/*metabolism
MH  - Fibroblasts/metabolism
MH  - Humans
MH  - Mice, Transgenic
MH  - Stromal Cells/*pathology
MH  - Tenascin/*metabolism
PMC - PMC4594615
OTO - NOTNLM
OT  - cancer
OT  - collagen
OT  - colorectal carcinoma
OT  - extracellular matrix
OT  - insulinoma
OT  - laminin
OT  - neuroendocrine tumor model
OT  - stromal cells
OT  - tenascin-C
OT  - tumor microenvironment
EDAT- 2015/01/23 06:00
MHDA- 2015/12/19 06:00
PMCR- 2016/01/22
CRDT- 2015/01/23 06:00
PHST- 2015/01/23 06:00 [entrez]
PHST- 2015/01/23 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
PHST- 2016/01/22 00:00 [pmc-release]
AID - 1005452 [pii]
AID - 10.1080/19336918.2015.1005452 [doi]
PST - ppublish
SO  - Cell Adh Migr. 2015;9(1-2):4-13. doi: 10.1080/19336918.2015.1005452.