PMID- 25611999
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 15
IP  - 2
DP  - 2015 Feb
TI  - Dramatic improvement of severe cryptococcosis-induced immune reconstitution 
      syndrome with adalimumab in a renal transplant recipient.
PG  - 560-4
LID - 10.1111/ajt.13002 [doi]
AB  - In solid organ transplant recipients, immune reconstitution inflammatory syndrome 
      (IRIS) is a rare complication of cryptococcosis, which may require steroids in 
      its most severe forms. Here, we report the case of a renal transplant recipient 
      who developed severe cryptococcal meningitis-associated IRIS 1 week after 
      immunosuppression reduction. High-dose steroids failed to improve the disease. 
      Finally, a recombinant human monoclonal tumor necrosis factor-alpha (TNF-alpha) 
      antagonist, adalimumab, was prescribed, and the patient rapidly experienced 
      dramatic neurological improvement. No IRIS relapse occurred within 14 months 
      following adalimumab discontinuation.
CI  - (c) Copyright 2015 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Scemla, A
AU  - Scemla A
AD  - Service de Nephrologie et Transplantation Adulte, Hopital Necker Enfants Malades, 
      Assistance Publique-Hopitaux de Paris, Universite Paris Descartes Sorbonne Paris 
      Cite, RTRS Centaure, Paris, France.
FAU - Gerber, S
AU  - Gerber S
FAU - Duquesne, A
AU  - Duquesne A
FAU - Parize, P
AU  - Parize P
FAU - Martinez, F
AU  - Martinez F
FAU - Anglicheau, D
AU  - Anglicheau D
FAU - Snanoudj, R
AU  - Snanoudj R
FAU - Zuber, M
AU  - Zuber M
FAU - Bougnoux, M-E
AU  - Bougnoux ME
FAU - Legendre, C
AU  - Legendre C
FAU - Lortholary, O
AU  - Lortholary O
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150121
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - FYS6T7F842 (Adalimumab)
SB  - IM
MH  - Adalimumab
MH  - Adult
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antibodies, Monoclonal, Humanized/*therapeutic use
MH  - Brain/pathology
MH  - Cryptococcosis/*complications
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy/*etiology
MH  - Immunosuppressive Agents
MH  - *Kidney Transplantation
MH  - Magnetic Resonance Imaging
MH  - Meningitis, Cryptococcal/drug therapy/etiology/pathology
MH  - *Severity of Illness Index
MH  - *Transplant Recipients
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
OTO - NOTNLM
OT  - antibiotic: antifungal, infection and infectious agents
OT  - clinical research/practice
OT  - fungal
OT  - immunosuppressant
OT  - infectious disease
OT  - kidney transplantation/nephrology
OT  - other
EDAT- 2015/01/23 06:00
MHDA- 2015/10/02 06:00
CRDT- 2015/01/23 06:00
PHST- 2014/04/15 00:00 [received]
PHST- 2014/08/07 00:00 [revised]
PHST- 2014/08/23 00:00 [accepted]
PHST- 2015/01/23 06:00 [entrez]
PHST- 2015/01/23 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
AID - S1600-6135(22)00044-2 [pii]
AID - 10.1111/ajt.13002 [doi]
PST - ppublish
SO  - Am J Transplant. 2015 Feb;15(2):560-4. doi: 10.1111/ajt.13002. Epub 2015 Jan 21.