PMID- 25612658
OWN - NLM
STAT- MEDLINE
DCOM- 20150710
LR  - 20181202
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 25
IP  - 3
DP  - 2015 May-Jun
TI  - Longitudinal modifications of the Ozurdex intravitreal implant as imaged by 
      SD-OCT.
PG  - 266-9
LID - 10.5301/ejo.5000551 [doi]
AB  - PURPOSE: To describe in vivo longitudinal modifications of the Ozurdex 
      intravitreal implant using spectral-domain optical coherence tomography (SD-OCT) 
      over a 6-month period in an eye treated for retinal vein occlusion (RVO). 
      METHODS: Case report. RESULTS: An 82-year-old woman with severe macular edema 
      secondary to branch RVO received an Ozurdex intravitreal implant in the left eye. 
      At day 1, SD-OCT showed that the implant was completely filled with highly 
      reflective dexamethasone. At day 30, complete resolution of macular edema on 
      SD-OCT was noted. At day 60, macular edema started to relapse; SD-OCT scans over 
      the implant showed highly reflective borders that appeared irregular and focally 
      retracted, while the majority of the internal drug had been washed out. At day 
      180, macular edema returned to baseline levels; SD-OCT scans over the implant 
      showed that the device was contracted with almost complete absence of the 
      internal lumen and drug. CONCLUSIONS: Using SD-OCT, we demonstrated that 60 days 
      postinjection most dexamethasone had been released from the Ozurdex implant, 
      which showed multiple irregularities. This was associated with recurrence of 
      macular edema that became worse after 180 days, when there was no residual 
      dexamethasone remaining in the shrunken implant. Low steady levels of the drug in 
      the vitreous and lower biological activity in the retina after the 2-month 
      high-dose release phase may explain why a large number of patients lose clinical 
      improvement 60 days postinjection, as shown by pivotal clinical trials.
FAU - Barteselli, Giulio
AU  - Barteselli G
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan 
      - Italy.
FAU - Dell'Arti, Laura
AU  - Dell'Arti L
FAU - Pinna, Valentina
AU  - Pinna V
FAU - Ratiglia, Roberto
AU  - Ratiglia R
FAU - Viola, Francesco
AU  - Viola F
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150115
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Drug Implants)
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Aged, 80 and over
MH  - Dexamethasone/*administration & dosage
MH  - *Drug Implants
MH  - Female
MH  - Follow-Up Studies
MH  - Glucocorticoids/*administration & dosage
MH  - Humans
MH  - Macular Edema/diagnosis/*drug therapy/etiology
MH  - Middle Aged
MH  - Recurrence
MH  - Retinal Vein Occlusion/complications/diagnosis/*drug therapy
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2015/01/24 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/01/24 06:00
PHST- 2014/12/03 00:00 [accepted]
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - F5915C51-613F-4CCB-B693-C262FB491D7B [pii]
AID - 10.5301/ejo.5000551 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2015 May-Jun;25(3):266-9. doi: 10.5301/ejo.5000551. Epub 2015 
      Jan 15.