PMID- 25612896
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20181113
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Oct 31
TI  - BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia 
      patients: a proof-of-concept study.
LID - pyu040 [pii]
LID - 10.1093/ijnp/pyu040 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been shown to be a 
      moderator of neuroplasticity. A frequent BDNF-polymorphism (Val66Met) is 
      associated with impairments of cortical plasticity. In patients with 
      schizophrenia, reduced neuroplastic responses following non-invasive brain 
      stimulation have been reported consistently. Various studies have indicated a 
      relationship between the BDNF-Val66Met-polymorphism and motor-cortical plasticity 
      in healthy individuals, but schizophrenia patients have yet to be investigated. 
      The aim of this proof-of-concept study was, therefore, to test the impact of the 
      BDNF-Val66Met-polymorphism on inhibitory and facilitatory cortical plasticity in 
      schizophrenia patients. METHODS: Cortical plasticity was investigated in 22 
      schizophrenia patients and 35 healthy controls using anodal and cathodal 
      transcranial direct-current stimulation (tDCS) applied to the left primary motor 
      cortex. Animal and human research indicates that excitability shifts following 
      anodal and cathodal tDCS are related to molecular long-term potentiation and 
      long-term depression. To test motor-cortical excitability before and after tDCS, 
      well-established single- and paired-pulse transcranial magnetic stimulation 
      protocols were applied. RESULTS: Our analysis revealed increased 
      glutamate-mediated intracortical facilitation in met-heterozygotes compared to 
      val-homozygotes at baseline. Following cathodal tDCS, schizophrenia 
      met-heterozygotes had reduced gamma-amino-butyric-acid-mediated short-interval 
      intracortical inhibition, whereas healthy met-heterozygotes displayed the 
      opposite effect. The BDNF-Val66Met-polymorphism did not influence single-pulse 
      motor-evoked potential amplitudes after tDCS. CONCLUSIONS: These preliminary 
      findings support the notion of an association of the BDNF-Val66Met-polymorphism 
      with observable alterations in plasticity following cathodal tDCS in 
      schizophrenia patients. This indicates a complex interaction between inhibitory 
      intracortical interneuron-networks, cortical plasticity, and the 
      BDNF-Val66Met-polymorphism. Further replication and validation need to be 
      dedicated to this question to confirm this relationship.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of CINP.
FAU - Strube, Wolfgang
AU  - Strube W
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel). 
      wolfgang.strube@med.uni-muenchen.de.
FAU - Nitsche, Michael A
AU  - Nitsche MA
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Wobrock, Thomas
AU  - Wobrock T
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Bunse, Tilmann
AU  - Bunse T
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Rein, Bettina
AU  - Rein B
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Herrmann, Maximiliane
AU  - Herrmann M
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Schmitt, Andrea
AU  - Schmitt A
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Nieratschker, Vanessa
AU  - Nieratschker V
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Witt, Stephanie H
AU  - Witt SH
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Rietschel, Marcella
AU  - Rietschel M
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Falkai, Peter
AU  - Falkai P
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
FAU - Hasan, Alkomiet
AU  - Hasan A
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany (Dr Strube, Bunse, Schmitt, Falkai, and Hasan); Department of Clinical 
      Neurophysiology, University of Goettingen, Goettingen, Germany (Dr Nitsche); 
      Centre of Mental Health, Darmstadt-Dieburg Clinics, Gross-Umstadt, Germany (Dr 
      Wobrock); Department of Psychiatry and Psychotherapy, University of Goettingen, 
      Goettingen, Germany (Drs Wobrock, Rein, and Herrmann); Laboratory of Neuroscience 
      (LIM27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil (Dr 
      Schmitt); Department of Genetic Epidemiology in Psychiatry, Central Institute of 
      Mental Health Mannheim Medical Faculty Mannheim/Heidelberg University, Germany 
      and Department of Psychiatry and Psychotherapy, University of Tuebingen, 
      Tuebingen, Germany (Dr Nieratschker); Department of Genetic Epidemiology in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University, Mannheim, Germany (Drs Witt and Rietschel).
LA  - eng
PT  - Journal Article
DEP - 20141031
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Evoked Potentials, Motor/genetics
MH  - Female
MH  - Genotyping Techniques
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiopathology
MH  - Neuronal Plasticity/*physiology
MH  - *Polymorphism, Genetic
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/drug therapy/*genetics/*physiopathology
MH  - Transcranial Direct Current Stimulation/methods
PMC - PMC4360229
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - motor-cortical plasticity
OT  - schizophrenia
OT  - transcranial direct current stimulation
OT  - transcranial magnetic stimulation
EDAT- 2015/01/24 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/01/21
CRDT- 2015/01/24 06:00
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/01/21 00:00 [pmc-release]
AID - pyu040 [pii]
AID - 10.1093/ijnp/pyu040 [doi]
PST - epublish
SO  - Int J Neuropsychopharmacol. 2014 Oct 31;18(4):pyu040. doi: 10.1093/ijnp/pyu040.