PMID- 25613316
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20181113
IS  - 2107-0180 (Electronic)
IS  - 0378-7966 (Linking)
VI  - 41
IP  - 3
DP  - 2016 Jun
TI  - A comparison of the pharmacokinetics of three different preparations of total 
      flavones of Hippophae rhamnoides in beagle dogs after oral administration.
PG  - 239-49
LID - 10.1007/s13318-015-0254-9 [doi]
AB  - Pharmacokinetic properties of isorhamnetin, quercetin, and kaempferol in three 
      different total flavones of Hippophae rhamnoides (TFH) preparations were compared 
      after oral administration to beagle dogs by a UPLC-MS method. The pharmacokinetic 
      results showed that C max of isorhamnetin and quercetin in TFH solid dispersion 
      (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly 
      enhanced than that in TFH preparations (p < 0.05). The AUCs of isorhamnetin and 
      quercetin in TFH-SD were 5.9- and 3.1-fold higher than that of TFH, while the 
      AUCs of isorhamnetin and quercetin in TFH-SE were 3.4- and 2.4-fold higher than 
      that of TFH. These findings suggested that the oral bioavailability of 
      isorhamnetin and quercetin in beagle dogs can be significantly increased in 
      TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to 
      explore the new forms for oral administration TFH and explain their in vivo 
      processes.
FAU - Duan, Jingze
AU  - Duan J
AD  - Research Center for Health and Nutrition, Shanghai University of Traditional 
      Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
AD  - Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, 201203, China.
FAU - Dang, Yang
AU  - Dang Y
AD  - Research Center for Health and Nutrition, Shanghai University of Traditional 
      Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
FAU - Meng, Houjun
AU  - Meng H
AD  - Research Center for Health and Nutrition, Shanghai University of Traditional 
      Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
AD  - Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, 201203, China.
FAU - Wang, Huizhen
AU  - Wang H
AD  - Research Center for Health and Nutrition, Shanghai University of Traditional 
      Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
FAU - Ma, Ping
AU  - Ma P
AD  - Global Pharmaceutical Research and Development, Hospira Inc., 1776 North 
      Centennial Drive, Mcpherson, KS, 67460, USA.
FAU - Li, Guowen
AU  - Li G
AD  - Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, 201203, China.
AD  - Pharmacy Department, Shanghai TCM-integrated Hospital, Shanghai, 200082, China.
FAU - Wu, Tao
AU  - Wu T
AD  - Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, 201203, China.
FAU - Xie, Yan
AU  - Xie Y
AD  - Research Center for Health and Nutrition, Shanghai University of Traditional 
      Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China. 
      rosexie_1996@hotmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150123
PL  - France
TA  - Eur J Drug Metab Pharmacokinet
JT  - European journal of drug metabolism and pharmacokinetics
JID - 7608491
RN  - 0 (Emulsions)
RN  - 0 (Flavones)
RN  - 0 (Kaempferols)
RN  - 07X3IB4R4Z (3-methylquercetin)
RN  - 731P2LE49E (kaempferol)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Biological Availability
MH  - Dogs
MH  - Emulsions/pharmacokinetics
MH  - Flavones/*pharmacokinetics
MH  - Hippophae/*chemistry
MH  - Kaempferols/pharmacokinetics
MH  - Male
MH  - Quercetin/analogs & derivatives/pharmacokinetics
OTO - NOTNLM
OT  - Beagle dogs
OT  - Pharmacokinetics
OT  - Self-emulsifying
OT  - Solid dispersion
OT  - Total flavones of Hippophae rhamnoides
OT  - UPLC-MS
EDAT- 2015/01/24 06:00
MHDA- 2017/03/30 06:00
CRDT- 2015/01/24 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
AID - 10.1007/s13318-015-0254-9 [pii]
AID - 10.1007/s13318-015-0254-9 [doi]
PST - ppublish
SO  - Eur J Drug Metab Pharmacokinet. 2016 Jun;41(3):239-49. doi: 
      10.1007/s13318-015-0254-9. Epub 2015 Jan 23.