PMID- 25613992
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20150330
IS  - 1878-4380 (Electronic)
IS  - 0966-842X (Linking)
VI  - 23
IP  - 4
DP  - 2015 Apr
TI  - HIV-1 adaptation to HLA: a window into virus-host immune interactions.
PG  - 212-24
LID - S0966-842X(14)00265-0 [pii]
LID - 10.1016/j.tim.2014.12.008 [doi]
AB  - HIV-1 develops specific mutations within its genome that allow it to escape 
      detection by human leukocyte antigen (HLA) class I-restricted immune responses, 
      notably those of CD8(+) cytotoxic T lymphocytes (CTL). HLA thus represents a 
      major force driving the evolution and diversification of HIV-1 within individuals 
      and at the population level. Importantly, the study of HIV-1 adaptation to HLA 
      also represents an opportunity to identify what qualities constitute an effective 
      immune response, how the virus in turn adapts to these pressures, and how we may 
      harness this information to design HIV-1 vaccines that stimulate effective 
      cellular immunity.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Carlson, Jonathan M
AU  - Carlson JM
AD  - Microsoft Research, Redmond, WA, USA.
FAU - Le, Anh Q
AU  - Le AQ
AD  - Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
FAU - Shahid, Aniqa
AU  - Shahid A
AD  - Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
FAU - Brumme, Zabrina L
AU  - Brumme ZL
AD  - Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British 
      Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic 
      address: zbrumme@sfu.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150119
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
RN  - 0 (AIDS Vaccines)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - AIDS Vaccines/genetics/immunology
MH  - Adaptation, Physiological
MH  - Animals
MH  - Antigen Presentation
MH  - Evolution, Molecular
MH  - Genetic Variation
MH  - HIV Infections/*immunology/*virology
MH  - HIV-1/genetics/immunology/*physiology
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - *Immune Evasion
MH  - Immunity, Cellular
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - T-Lymphocytes, Cytotoxic/*virology
OTO - NOTNLM
OT  - CD8(+) T-lymphocyte (CTL)
OT  - adaptation
OT  - evolution
OT  - human immunodeficiency virus 1 (HIV-1)
OT  - human leukocyte antigen (HLA) class I
OT  - immune escape
EDAT- 2015/01/24 06:00
MHDA- 2015/07/24 06:00
CRDT- 2015/01/24 06:00
PHST- 2014/10/13 00:00 [received]
PHST- 2014/12/04 00:00 [revised]
PHST- 2014/12/16 00:00 [accepted]
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - S0966-842X(14)00265-0 [pii]
AID - 10.1016/j.tim.2014.12.008 [doi]
PST - ppublish
SO  - Trends Microbiol. 2015 Apr;23(4):212-24. doi: 10.1016/j.tim.2014.12.008. Epub 
      2015 Jan 19.