PMID- 25615956
OWN - NLM
STAT- MEDLINE
DCOM- 20160121
LR  - 20150403
IS  - 1898-4002 (Electronic)
IS  - 1896-1126 (Linking)
VI  - 60
IP  - 1
DP  - 2015 Mar
TI  - No association between vitamin D levels and inflammation markers in patients with 
      acute coronary syndrome.
PG  - 89-93
LID - S1896-1126(14)00101-1 [pii]
LID - 10.1016/j.advms.2014.12.003 [doi]
AB  - PURPOSE: A modern concept regards acute coronary syndrome (ACS) as an 
      auto-inflammatory disorder. The purpose of the present study is to assess the 
      plasma levels of inflammation related to biomarkers and cytokines in ACS patients 
      and to correlate the values with 25-hydroxy vitamin D3 (calcidiol). There are no 
      previously published reports concerning serum concentrations of inflammatory 
      markers in patients with hypovitaminosis D in ACS. PATIENTS AND METHODS: 
      Eighty-eight consecutive patients with ACS [n=47 ST elevation myocardial 
      infarction (STEMI), n=41 unstable angina pectoris (USAP)] were enrolled within 
      12h after symptoms. The blood samples were collected on admission in order to 
      evaluate calcidiol, serum amyloid A (SAA), interleukin (IL)-6, interleukin 
      (IL)-10, tumor necrosis factor-alpha (TNFalpha) and high sensitivity C-reactive 
      protein (hsCRP). RESULTS: Calcidiol, TNFalpha and SAA levels were significantly lower 
      (p=0.01, p<0.01 and p<0.01 respectively), whereas hsCRP levels were significantly 
      higher (p<0.01) in STEMI group as compared to USAP group. In the STEMI group, 
      there were negative correlations between SAA and hsCRP (r=-0.347; p=0.01) and SAA 
      and IL-6 (r=-0.356; p=0.01). There was a positive correlation between IL-6 and 
      hsCRP (r=0.529; p<0.01). In the USAP group, it was found that there were a strong 
      negative correlation between SAA and hsCRP (r=-0.75; p<0.01) and a positive 
      correlation between IL-6 and TNF-alpha (r=0.54; p<0.01). CONCLUSION: This study 
      demonstrates that calcidiol levels are not associated with the inflammation 
      markers in patients with acute phase ACS.
CI  - Copyright (c) 2014 Medical University of Bialystok. Published by Elsevier Urban & 
      Partner Sp. z o.o. All rights reserved.
FAU - Eren, Esin
AU  - Eren E
AD  - Antalya Public Health Center of Ministry of Health, Antalya, Turkey. Electronic 
      address: esinerendr@gmail.com.
FAU - Ellidag, Hamit Yasar
AU  - Ellidag HY
AD  - Central Laboratories of Antalya Education and Research Hospital of Ministry of 
      Health, Antalya, Turkey.
FAU - Yilmaz, Akar
AU  - Yilmaz A
AD  - Cardiology of Antalya Education and Research Hospital of Ministry of Health, 
      Antalya, Turkey.
FAU - Aydin, Ozgur
AU  - Aydin O
AD  - Central Laboratories of Antalya Education and Research Hospital of Ministry of 
      Health, Antalya, Turkey.
FAU - Yilmaz, Necat
AU  - Yilmaz N
AD  - Central Laboratories of Antalya Education and Research Hospital of Ministry of 
      Health, Antalya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150103
PL  - Netherlands
TA  - Adv Med Sci
JT  - Advances in medical sciences
JID - 101276222
RN  - 0 (Biomarkers)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Acute Coronary Syndrome/*blood
MH  - Aged
MH  - Biomarkers/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Serum Amyloid A Protein/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Vitamin D/*blood
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Interleukin-10
OT  - Interleukin-6
OT  - Serum amyloid A
OT  - Vitamin D
EDAT- 2015/01/24 06:00
MHDA- 2016/01/23 06:00
CRDT- 2015/01/24 06:00
PHST- 2014/05/08 00:00 [received]
PHST- 2014/12/01 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2016/01/23 06:00 [medline]
AID - S1896-1126(14)00101-1 [pii]
AID - 10.1016/j.advms.2014.12.003 [doi]
PST - ppublish
SO  - Adv Med Sci. 2015 Mar;60(1):89-93. doi: 10.1016/j.advms.2014.12.003. Epub 2015 
      Jan 3.