PMID- 25616042
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20220408
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 90
IP  - 5
DP  - 2015 May
TI  - Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation 
      in sickle cell pain crisis.
PG  - 381-5
LID - 10.1002/ajh.23956 [doi]
AB  - Intravenous immunoglobulin (IVIG) decreases neutrophil adhesion to endothelium 
      and red blood cell-neutrophil interactions in sickle cell mice undergoing 
      vaso-occlusion. In this Phase I clinical trial of sickle cell anemia (SCA) 
      patients admitted with pain crisis, we evaluated the status of adhesion molecules 
      on neutrophils in control and IVIG-treated subjects pre- and post-infusion up to 
      800 mg/kg, the same dose used in murine studies. Mac-1 function significantly 
      decreased from baseline in the low-dose IVIG (200-400 mg/kg) cohorts. 
      IVIG-related adverse events may have occurred in the high-dose (600-800 mg/kg) 
      cohorts. There were no significant increases in neutrophil and leukocyte counts, 
      suggesting that IVIG may more selectively inhibit Mac-1 function as opposed to 
      neutrophil adhesion. This study provides the first in-human validation of 
      pre-clinical murine studies that IVIG can decrease Mac-1 function.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Manwani, Deepa
AU  - Manwani D
AD  - Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
FAU - Chen, Grace
AU  - Chen G
AD  - Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
FAU - Carullo, Veronica
AU  - Carullo V
AD  - Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New 
      York
FAU - Serban, Stelian
AU  - Serban S
AD  - Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York
FAU - Olowokure, Olugbenga
AU  - Olowokure O
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York
FAU - Jang, Jungeun
AU  - Jang J
AD  - Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
FAU - Huggins, Matthew
AU  - Huggins M
AD  - Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
FAU - Cohen, Hillel W
AU  - Cohen HW
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, New York
FAU - Billett, Henny
AU  - Billett H
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
FAU - Atweh, George F
AU  - Atweh GF
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York
FAU - Frenette, Paul S
AU  - Frenette PS
AD  - Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
AD  - Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine 
      Research, Albert Einstein College of Medicine, Bronx, New York
FAU - Shi, Patricia A
AU  - Shi PA
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
AD  - New York Blood Center, New York, New York
LA  - eng
GR  - K23 HL089217/HL/NHLBI NIH HHS/United States
GR  - TL1 TR001072/TR/NCATS NIH HHS/United States
GR  - R01 HL069438/HL/NHLBI NIH HHS/United States
GR  - 1 TL1 TR00107 2-01/TR/NCATS NIH HHS/United States
GR  - KL2 TR001071/TR/NCATS NIH HHS/United States
GR  - K23HL089217/HL/NHLBI NIH HHS/United States
GR  - R01FD003447/FD/FDA HHS/United States
GR  - R01 FD003447/FD/FDA HHS/United States
GR  - 1 KL2 TR001071 -01/TR/NCATS NIH HHS/United States
GR  - UL1 TR001073/TR/NCATS NIH HHS/United States
GR  - 1 UL1 TR0010 73-01/TR/NCATS NIH HHS/United States
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20150401
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Macrophage-1 Antigen)
SB  - IM
MH  - Acute Chest Syndrome/blood/complications/*drug therapy/physiopathology
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/blood/complications/*drug therapy/physiopathology
MH  - Cell Adhesion/drug effects
MH  - Child
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Macrophage-1 Antigen/*blood
MH  - Male
MH  - Neutrophil Activation/drug effects
MH  - Neutrophils/*drug effects/metabolism/pathology
MH  - Pain/blood/complications/*drug therapy/physiopathology
PMC - PMC4409477
MID - NIHMS659240
COIS- The authors report no relevant conflict of interests.
EDAT- 2015/01/24 06:00
MHDA- 2015/06/24 06:00
PMCR- 2016/05/01
CRDT- 2015/01/24 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/01/20 00:00 [accepted]
PHST- 2015/01/24 06:00 [entrez]
PHST- 2015/01/24 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 10.1002/ajh.23956 [doi]
PST - ppublish
SO  - Am J Hematol. 2015 May;90(5):381-5. doi: 10.1002/ajh.23956. Epub 2015 Apr 1.