PMID- 25616498
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 31
IP  - 4
DP  - 2016 Apr
TI  - Additive clinical value of serum brain-derived neurotrophic factor for prediction 
      of chronic heart failure outcome.
PG  - 535-44
LID - 10.1007/s00380-015-0628-6 [doi]
AB  - The importance of the central nervous system in cardiovascular events has been 
      recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the 
      neurotrophic factor family, is involved in depression mechanisms and also in 
      stress and anxiety. Because BDNF is reported about cardioprotective role, we 
      elucidated whether BDNF is associated with cardiovascular events in patients with 
      chronic heart failure (CHF). We examined serum BDNF levels in 134 patients with 
      CHF and 23 control subjects. The patients were followed to register cardiac 
      events for a median of 426 days. BDNF was significantly lower in CHF patients 
      than in control subjects (25.8 +/- 8.4 vs 14.7 +/- 8.4, P < 0.0001). Serum BDNF was 
      also lower in patients with cardiac events than in event-free patients (16.1 +/- 
      8.0 vs 12.5 +/- 8.5, P < 0.0001). The cutoff value of BDNF was determined by 
      performing receiver operating characteristic curve analysis. Kaplan-Meier 
      analysis demonstrated that patients with low levels of BDNF experienced higher 
      rates of cardiac events than those with high levels of BDNF. Multivariate Cox 
      hazard analysis demonstrated that low BDNF levels (</=12.4 ng/mL) were an 
      independent prognostic factor for cardiac events (hazard ratio 2.932, 95 % 
      confidence interval 1.622-5.301; P = 0.0004). Adding levels of BDNF to the model 
      with BNP levels, age, and eGFR for the prediction of cardiac events yielded 
      significant net reclassification improvement of 0.429 (P < 0.001) and an 
      integrated discrimination improvement of 0.101 (P < 0.001). Low serum BDNF levels 
      were found in patients with CHF, and these levels were found to be independently 
      associated with an increased risk of cardiac events.
FAU - Kadowaki, Shinpei
AU  - Kadowaki S
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Shishido, Tetsuro
AU  - Shishido T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan. 
      tshishid@med.id.yamagata-u.ac.jp.
FAU - Honda, Yuki
AU  - Honda Y
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Narumi, Taro
AU  - Narumi T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Otaki, Yoichiro
AU  - Otaki Y
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Kinoshita, Daisuke
AU  - Kinoshita D
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Nishiyama, Satoshi
AU  - Nishiyama S
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Takahashi, Hiroki
AU  - Takahashi H
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Arimoto, Takanori
AU  - Arimoto T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Miyamoto, Takuya
AU  - Miyamoto T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Watanabe, Tetsu
AU  - Watanabe T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
FAU - Kubota, Isao
AU  - Kubota I
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150124
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Disease Progression
MH  - Echocardiography
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/*blood/diagnosis/epidemiology
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prognosis
MH  - ROC Curve
MH  - Radiography, Thoracic
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate/trends
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Heart failure
OT  - Prognosis
OT  - Risk stratification
EDAT- 2015/01/27 06:00
MHDA- 2017/01/10 06:00
CRDT- 2015/01/25 06:00
PHST- 2014/03/14 00:00 [received]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/01/25 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - 10.1007/s00380-015-0628-6 [pii]
AID - 10.1007/s00380-015-0628-6 [doi]
PST - ppublish
SO  - Heart Vessels. 2016 Apr;31(4):535-44. doi: 10.1007/s00380-015-0628-6. Epub 2015 
      Jan 24.