PMID- 25618406
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20181113
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 18
IP  - 8
DP  - 2015 Jan 24
TI  - Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through 
      Promotion of BDNF Signaling Pathway.
LID - pyv010 [pii]
LID - 10.1093/ijnp/pyv010 [doi]
AB  - BACKGROUND: Current antidepressants are clinically effective only after several 
      weeks of administration. Tetramethylpyrazine (TMP) is an identified component of 
      Ligusticum wallichii with neuroprotective effects. Here, we investigated the 
      antidepressant effects of TMP in mice models of depression. METHODS: 
      Antidepressant effects of TMP were first detected in the forced swim test (FST) 
      and tail suspension test (TST), and further assessed in the chronic social defeat 
      stress (CSDS) model. Changes in the brain-derived neurotrophic factor (BDNF) 
      signaling pathway and in hippocampal neurogenesis after CSDS and TMP treatment 
      were then investigated. A tryptophan hydroxylase inhibitor and BDNF signaling 
      inhibitors were also used to determine the mechanisms of TMP. RESULTS: TMP 
      exhibited potent antidepressant effects in the FST and TST without affecting 
      locomotor activity. TMP also prevented the CSDS-induced symptoms. Moreover, TMP 
      completely restored the CSDS-induced decrease of BDNF signaling pathway and 
      hippocampal neurogenesis. Furthermore, a blockade of the BDNF signaling pathway 
      prevented the antidepressant effects of TMP, while TMP produced no influence on 
      the monoaminergic system. CONCLUSIONS: In conclusion, these data provide the 
      first evidence that TMP has antidepressant effects, and this was mediated by 
      promoting the BDNF signaling pathway.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of CINP.
FAU - Jiang, Bo
AU  - Jiang B
AD  - Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, 
      Jiangsu, China (Drs Jiang, Huang, Chen, Tong, and Zhang).
FAU - Huang, Chao
AU  - Huang C
AD  - Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, 
      Jiangsu, China (Drs Jiang, Huang, Chen, Tong, and Zhang).
FAU - Chen, Xiang-Fan
AU  - Chen XF
AD  - Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, 
      Jiangsu, China (Drs Jiang, Huang, Chen, Tong, and Zhang).
FAU - Tong, Li-Juan
AU  - Tong LJ
AD  - Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, 
      Jiangsu, China (Drs Jiang, Huang, Chen, Tong, and Zhang).
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Pharmacology, Pharmacy College, Nantong University, Nantong 226001, 
      Jiangsu, China (Drs Jiang, Huang, Chen, Tong, and Zhang) huanghezhi36020@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150124
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Pyrazines)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - V80F4IA5XG (tetramethylpyrazine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/physiology
MH  - Neurogenesis/drug effects/physiology
MH  - Neuropsychological Tests
MH  - Pyrazines/*pharmacology
MH  - Signal Transduction/drug effects
MH  - Tryptophan Hydroxylase/antagonists & inhibitors/metabolism
PMC - PMC4571627
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - chronic social defeat stress
OT  - depression
OT  - hippocampal neurogenesis
OT  - tetramethylpyrazine
EDAT- 2015/01/27 06:00
MHDA- 2016/02/26 06:00
PMCR- 2015/03/06
CRDT- 2015/01/26 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2015/01/22 00:00 [accepted]
PHST- 2015/01/26 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PHST- 2015/03/06 00:00 [pmc-release]
AID - pyv010 [pii]
AID - 10.1093/ijnp/pyv010 [doi]
PST - epublish
SO  - Int J Neuropsychopharmacol. 2015 Jan 24;18(8):pyv010. doi: 10.1093/ijnp/pyv010.