PMID- 25619430
OWN - NLM
STAT- MEDLINE
DCOM- 20151105
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 226
IP  - 1
DP  - 2015 Mar 30
TI  - Hypothalamic-pituitary-adrenal axis activity in patients with pathological 
      gambling and internet use disorder.
PG  - 97-102
LID - S0165-1781(14)01005-1 [pii]
LID - 10.1016/j.psychres.2014.11.078 [doi]
AB  - Alterations in secretion of stress hormones within the 
      hypothalamic-pituitary-adrenal (HPA) axis have repeatedly been found in 
      substance-related addictive disorders. It has been suggested that glucocorticoids 
      might contribute to the development and maintenance of substance use disorders by 
      facilitatory effects on behavioral responses to substances of abuse. The 
      objective of this pilot study was to investigate HPA axis activity in patients 
      with non-substance-related addictive disorders, i.e. pathological gambling and 
      internet use disorder. We measured plasma levels of copeptin, a vasopressin 
      surrogate marker, adrenocorticotropic hormone (ACTH) and cortisol in male 
      patients with pathological gambling (n=14), internet use disorder (n=11) and 
      matched healthy controls for pathological gambling (n=13) and internet use 
      disorder (n=10). Plasma levels of copeptin, ACTH and cortisol in patients with 
      pathological gambling or internet use disorder did not differ among groups. 
      However, cortisol plasma levels correlated negatively with the severity of 
      pathological gambling as measured by the PG-YBOCS. Together with our findings of 
      increased serum levels of brain-derived neurotrophic factor (BDNF) in 
      pathological gambling but not internet use disorder, these results suggest that 
      the pathophysiology of pathological gambling shares some characteristics with 
      substance-related addictive disorders on a neuroendocrinological level, whereas 
      those similarities could not be observed in internet use disorder.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Geisel, Olga
AU  - Geisel O
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin Chariteplatz 1, 10117 Berlin, Germany. Electronic address: 
      olga.geisel@charite.de.
FAU - Panneck, Patricia
AU  - Panneck P
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin Chariteplatz 1, 10117 Berlin, Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin Chariteplatz 1, 10117 Berlin, Germany.
FAU - Wiedemann, Klaus
AU  - Wiedemann K
AD  - Department of Psychiatry, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 
      52, 20246 Hamburg, Germany.
FAU - Muller, Christian A
AU  - Muller CA
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin Chariteplatz 1, 10117 Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20141219
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Behavior, Addictive/blood/*physiopathology
MH  - Brain-Derived Neurotrophic Factor
MH  - Gambling/blood/*physiopathology
MH  - Glycopeptides/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypothalamo-Hypophyseal System/*physiopathology
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Pituitary-Adrenal System/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Adrenocorticotropic hormone
OT  - Cortisol
OT  - HPA axis
OT  - Internet use disorder
OT  - Pathological gambling
OT  - Vasopressin
EDAT- 2015/01/27 06:00
MHDA- 2015/11/06 06:00
CRDT- 2015/01/27 06:00
PHST- 2014/08/12 00:00 [received]
PHST- 2014/10/08 00:00 [revised]
PHST- 2014/11/24 00:00 [accepted]
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2015/11/06 06:00 [medline]
AID - S0165-1781(14)01005-1 [pii]
AID - 10.1016/j.psychres.2014.11.078 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Mar 30;226(1):97-102. doi: 10.1016/j.psychres.2014.11.078. 
      Epub 2014 Dec 19.