PMID- 25619659
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20231213
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 85
IP  - 3
DP  - 2015 Feb 4
TI  - High salt intake increases blood pressure via BDNF-mediated downregulation of 
      KCC2 and impaired baroreflex inhibition of vasopressin neurons.
PG  - 549-60
LID - S0896-6273(14)01157-X [pii]
LID - 10.1016/j.neuron.2014.12.048 [doi]
AB  - The mechanisms by which dietary salt promotes hypertension are unknown. Previous 
      work established that plasma [Na(+)] and osmolality rise in proportion with salt 
      intake and thus promote release of vasopressin (VP) from the neurohypophysis. 
      Although high levels of circulating VP can increase blood pressure, this effect 
      is normally prevented by a potent GABAergic inhibition of VP neurons by aortic 
      baroreceptors. Here we show that chronic high salt intake impairs baroreceptor 
      inhibition of rat VP neurons through a brain-derived neurotrophic factor 
      (BDNF)-dependent activation of TrkB receptors and downregulation of KCC2 
      expression, which prevents inhibitory GABAergic signaling. We show that high salt 
      intake increases the spontaneous firing rate of VP neurons in vivo and that 
      circulating VP contributes significantly to the elevation of arterial pressure 
      under these conditions. These results provide the first demonstration that 
      dietary salt can affect blood pressure through neurotrophin-induced plasticity in 
      a central homeostatic circuit.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Choe, Katrina Y
AU  - Choe KY
AD  - Centre for Research in Neuroscience, Research Institute of the McGill University 
      Health Centre, 1650 Cedar Avenue, Montreal, QC H3G1A4, Canada.
FAU - Han, Su Y
AU  - Han SY
AD  - Centre for Neuroendocrinology and Department of Physiology, University of Otago, 
      Dunedin 9054, New Zealand.
FAU - Gaub, Perrine
AU  - Gaub P
AD  - Montreal Neurological Institute, 3801 University Street, Montreal, QC H3A2B4, 
      Canada.
FAU - Shell, Brent
AU  - Shell B
AD  - Department of Integrative Physiology, University of North Texas Health Sciences 
      Centre, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
FAU - Voisin, Daniel L
AU  - Voisin DL
AD  - Neurocentre Magendie, INSERM U862, 146, rue Leo Saignat, 33077 Bordeaux, France.
FAU - Knapp, Blayne A
AU  - Knapp BA
AD  - Department of Integrative Physiology, University of North Texas Health Sciences 
      Centre, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
FAU - Barker, Philip A
AU  - Barker PA
AD  - Montreal Neurological Institute, 3801 University Street, Montreal, QC H3A2B4, 
      Canada.
FAU - Brown, Colin H
AU  - Brown CH
AD  - Centre for Neuroendocrinology and Department of Physiology, University of Otago, 
      Dunedin 9054, New Zealand.
FAU - Cunningham, J Thomas
AU  - Cunningham JT
AD  - Department of Integrative Physiology, University of North Texas Health Sciences 
      Centre, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
FAU - Bourque, Charles W
AU  - Bourque CW
AD  - Centre for Research in Neuroscience, Research Institute of the McGill University 
      Health Centre, 1650 Cedar Avenue, Montreal, QC H3G1A4, Canada. Electronic 
      address: charles.bourque@mcgill.ca.
LA  - eng
GR  - R56 HL062579/HL/NHLBI NIH HHS/United States
GR  - R01 HL119458/HL/NHLBI NIH HHS/United States
GR  - MOP-9939/Canadian Institutes of Health Research/Canada
GR  - T32 AG020494/AG/NIA NIH HHS/United States
GR  - FRN37850/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150122
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (Symporters)
RN  - 11000-17-2 (Vasopressins)
SB  - IM
CIN - Nat Rev Neurosci. 2015 Mar;16(3):125. PMID: 25669741
CIN - Cell Metab. 2015 Apr 7;21(4):509-10. PMID: 25863241
MH  - Animals
MH  - Baroreflex/drug effects/*physiology
MH  - Blood Pressure/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology/physiology
MH  - Down-Regulation/drug effects/physiology
MH  - Hypertension/chemically induced/metabolism
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Organ Culture Techniques
MH  - Rats
MH  - Rats, Long-Evans
MH  - Sodium Chloride, Dietary/*adverse effects
MH  - Symporters/*metabolism
MH  - Vasopressins/*metabolism
MH  - K Cl- Cotransporters
PMC - PMC4577058
MID - NIHMS722000
EDAT- 2015/01/27 06:00
MHDA- 2015/06/16 06:00
PMCR- 2015/09/21
CRDT- 2015/01/27 06:00
PHST- 2013/06/23 00:00 [received]
PHST- 2014/11/10 00:00 [revised]
PHST- 2014/12/17 00:00 [accepted]
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2015/09/21 00:00 [pmc-release]
AID - S0896-6273(14)01157-X [pii]
AID - 10.1016/j.neuron.2014.12.048 [doi]
PST - ppublish
SO  - Neuron. 2015 Feb 4;85(3):549-60. doi: 10.1016/j.neuron.2014.12.048. Epub 2015 Jan 
      22.