PMID- 25620350
OWN - NLM
STAT- MEDLINE
DCOM- 20160122
LR  - 20221207
IS  - 1751-2980 (Electronic)
IS  - 1751-2972 (Linking)
VI  - 16
IP  - 4
DP  - 2015 Apr
TI  - The -A2518G polymorphism in the MCP-1 gene and inflammatory bowel disease risk: A 
      meta-analysis.
PG  - 177-85
LID - 10.1111/1751-2980.12232 [doi]
AB  - OBJECTIVE: The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene 
      polymorphism has been found to be involved in the susceptibility to inflammatory 
      bowel disease (IBD); however, the results of existing studies are controversial. 
      The aim of this meta-analysis was to assess the relationship between the MCP-1 
      -A2518G polymorphism and the risk of IBD. METHODS: PubMed, EMBASE and MEDLINE 
      were searched for studies assessing the relationship between the -A2518G 
      polymorphism in MCP-1 gene and the risk of IBD. Available data were extracted and 
      statistically analyzed using STATA 12.0. RESULTS: A total of five publications 
      involving 3137 individuals (1818 IBD cases and 1319 controls) were included in 
      the meta-analysis. A combined analysis revealed that the MCP-1 -A2518G 
      polymorphism in was a protective factor for GG + AG vs AA (OR 0.76, 95% CI 
      0.67-0.87, P = 0.000). Subgroup analysis by ethnicity showed that among European 
      patients the AG + GG homozygote, unlike the AA homozygote, had a protective 
      effect against IBD (OR 0.73, 95% CI 0.63-0.84, P = 0.000), but did not do so 
      among Asian and African patients. Subgroup analysis by disease subtype suggested 
      the -A2518G polymorphism in MCP-1 had a protective effect against Crohn's disease 
      (OR 0.69, 95% CI 0.58-0.81, P = 0.000), but not against ulcerative colitis. 
      CONCLUSIONS: Our meta-analysis suggested that the -A2518G polymorphism in MCP-1 
      may be a protective factor for IBD in European populations. Further studies are 
      required to confirm these findings.
CI  - (c) 2015 Chinese Medical Association Shanghai Branch, Chinese Society of 
      Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University 
      School of Medicine and Wiley Publishing Asia Pty Ltd.
FAU - Li, Yu Wen
AU  - Li YW
AD  - Division of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province, China.
FAU - Yang, Ci Qiu
AU  - Yang CQ
FAU - Xiao, Ying Lian
AU  - Xiao YL
FAU - Li, Jie
AU  - Li J
FAU - Xie, Chen Xi
AU  - Xie CX
FAU - Zhang, Sheng Hong
AU  - Zhang SH
FAU - Yu, Qiao
AU  - Yu Q
FAU - Wang, Hui Ling
AU  - Wang HL
FAU - Lu, Wei Ming
AU  - Lu WM
FAU - Chen, Min Hu
AU  - Chen MH
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - J Dig Dis
JT  - Journal of digestive diseases
JID - 101302699
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People/genetics
MH  - Black People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Inflammatory Bowel Diseases/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - White People/genetics
OTO - NOTNLM
OT  - inflammatory bowel disease
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
OT  - polymorphism
OT  - susceptibility
EDAT- 2015/01/27 06:00
MHDA- 2016/01/23 06:00
CRDT- 2015/01/27 06:00
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2016/01/23 06:00 [medline]
AID - 10.1111/1751-2980.12232 [doi]
PST - ppublish
SO  - J Dig Dis. 2015 Apr;16(4):177-85. doi: 10.1111/1751-2980.12232.