PMID- 25620428
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20150415
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 104
IP  - 5
DP  - 2015 May
TI  - The diagnostic criteria for allergic bronchopulmonary aspergillosis in children 
      with poorly controlled asthma need to be re-evaluated.
PG  - e206-9
LID - 10.1111/apa.12930 [doi]
AB  - AIM: The aim of this study was to examine the association between allergic 
      bronchopulmonary aspergillosis (ABPA) and poorly controlled asthma in children 
      and appraise the diagnostic criteria. METHODS: The study included 100 children 
      with poorly controlled asthma. We diagnosed ABPA using the Aspergillus skin test, 
      pulmonary function test, total and specific immunoglobulin E (IgE) to Aspergillus 
      fumigatus, chest radiograph and high-resolution computed tomography. Patients 
      were diagnosed and classified according to the Rosenberg-Patterson criteria for 
      ABPA. The cut-off value for total serum IgE was calculated by receiver operating 
      characteristics curve analysis. RESULTS: Of 100 children with poorly controlled 
      asthma, 26 patients were ABPA positive. There was a significant difference in the 
      forced expiratory volume in 1-sec/forced vital capacity ratio between ABPA 
      positive (0.78 +/- 0.14) and negative (0.87 +/- 0.15) children (p = 0.008). ABPA 
      positive children were categorised as seropositive, central bronchiectasis and 
      other radiological findings. The receiver operating characteristics curve was 
      constructed, and a value of 1200 IU/mL of total IgE was observed, with 88.5% 
      sensitivity and 70.5% specificity. CONCLUSION: This study showed an association 
      between ABPA and poorly controlled asthma in children and suggests a higher 
      cut-off value of total IgE for the diagnosis of ABPA.
CI  - (c)2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Singh, Meenu
AU  - Singh M
AD  - Advanced Pediatric Centre, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Das, Subhamoy
AU  - Das S
FAU - Chauhan, Anil
AU  - Chauhan A
FAU - Paul, Nandini
AU  - Paul N
FAU - Sodhi, Kushaljit Singh
AU  - Sodhi KS
FAU - Mathew, Joseph
AU  - Mathew J
FAU - Chakrabarti, Arunaloke
AU  - Chakrabarti A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20150313
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Aspergillosis, Allergic Bronchopulmonary/blood/*diagnosis/immunology
MH  - Aspergillus fumigatus/*immunology
MH  - Asthma/blood/complications/immunology/*microbiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Respiratory Function Tests
OTO - NOTNLM
OT  - Airway inflammation
OT  - Allergy
OT  - Asthma
EDAT- 2015/01/27 06:00
MHDA- 2016/01/26 06:00
CRDT- 2015/01/27 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - 10.1111/apa.12930 [doi]
PST - ppublish
SO  - Acta Paediatr. 2015 May;104(5):e206-9. doi: 10.1111/apa.12930. Epub 2015 Mar 13.