PMID- 25620712
OWN - NLM
STAT- MEDLINE
DCOM- 20151216
LR  - 20150330
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 24
IP  - 4
DP  - 2015 Apr
TI  - Elevated homocysteine levels contribute to larger hematoma volume in patients 
      with intracerebral hemorrhage.
PG  - 784-8
LID - S1052-3057(14)00548-5 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2014.11.005 [doi]
AB  - BACKGROUND: We investigate whether plasma homocysteine (HCY) levels are 
      associated with hematoma volume and outcome in patients with intracerebral 
      hemorrhage (ICH). METHODS: A total of 69 patients admitted within 24 hours after 
      ICH onset was divided into 2 groups based on admission plasma HCY levels (low 
      homocysteinemia [LHCY] group, plasma HCY concentrations </=14.62 mumol/L, versus 
      high homocysteinemia [HHCY] group, >14.62 mumol/L). RESULTS: Mean hematoma volumes 
      for 2 groups (LHCY and HHCY) were 13.18 and 23.09 mL (P = .012), respectively, in 
      patients with thalamoganglionic ICH, but hematoma volumes between 2 groups had no 
      significant difference among patients with lobar or infratentorial ICH. On 
      multivariate linear regression analysis, elevated HCY levels significantly 
      correlated with larger hematoma volume in patients with thalamoganglionic 
      ICH (B = .604, P = .004) after adjustment for confounding factors. Poor outcomes 
      (6-month modified Rankin Scale scores >/=3) were not significantly different 
      between 2 groups (low homocysteinemia group, 31.4%, versus high homocysteinemia 
      group, 41.2%, P = .400). CONCLUSIONS: Elevated plasma HCY levels were associated 
      with larger hematoma volume only in patients with thalamoganglionic ICH. 
      HCY levels might not be predictors of the 6-month clinical outcome in patients 
      with ICH.
CI  - Copyright (c) 2015 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Zhou, Fangfang
AU  - Zhou F
AD  - Department of Neurology, Second Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Chen, Botao
AU  - Chen B
AD  - Department of General Surgery, Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Chen, Chunli
AU  - Chen C
AD  - Department of Neurology, Second Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Huang, Jinjin
AU  - Huang J
AD  - Department of Hemotology, Second Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Chen, Shiyu
AU  - Chen S
AD  - Department of Neurology, Second Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Guo, Fulin
AU  - Guo F
AD  - Department of Anesthesiology, Xiangya Hospital of Central South University, 
      Changsha, P.R. China.
FAU - Hu, Zhiping
AU  - Hu Z
AD  - Department of Neurology, Second Xiangya Hospital of Central South University, 
      Changsha, P.R. China. Electronic address: zhipinghuxy@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20150122
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Cerebral Hemorrhage/*complications
MH  - Chi-Square Distribution
MH  - Female
MH  - Hematoma/*blood/*etiology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Thalamus/pathology
OTO - NOTNLM
OT  - Stroke
OT  - hematoma
OT  - homocysteine
OT  - intracerebral hemorrhage
OT  - stroke outcome
EDAT- 2015/01/27 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/01/27 06:00
PHST- 2014/10/09 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/11/10 00:00 [accepted]
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - S1052-3057(14)00548-5 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2014.11.005 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2015 Apr;24(4):784-8. doi: 
      10.1016/j.jstrokecerebrovasdis.2014.11.005. Epub 2015 Jan 22.