PMID- 25621254
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150126
LR  - 20201001
IS  - 2231-3796 (Print)
IS  - 0973-7707 (Electronic)
IS  - 2231-3796 (Linking)
VI  - 67
IP  - Suppl 1
DP  - 2015 Mar
TI  - Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous 
      Cell Carcinoma: A PCR Approach.
PG  - 51-5
LID - 10.1007/s12070-014-0750-2 [doi]
AB  - Helicobacter pylori is a gram-negative bacillus causing benign and malignant 
      gastric diseases such as gastroesophageal reflux (GER). In larynx, H. pylori 
      causes chronic inflammation and mucosal destruction that may lead to malignant 
      changes. Although, H. pylori poses several virulence factors, cagA is probably 
      the main factor in this regard. To evaluate the role of cagA gene in laryngeal 
      squamous cell carcinoma (LSCC), a case-control study was conducted on patients 
      with laryngeal complaints during 2010-2012. Seventy-two patients with LSCC (case 
      group) and 72 patients without malignancy (control group) were included in the 
      study. The H. pylori and cagA factor were assessed in laryngeal specimen of 
      patients with PCR technique. 33 % of patients in case group (24 patients) and 
      45.8 % (33 patients) of control group were positive for H. pylori. CagA gene was 
      present in 13.8 % (10 patients) of case group specimens and 31.9 % (23 patients) 
      of control group. This difference was statistically significant with 
      Mantel-Haenszel statistical test analyses. The results showed that patients with 
      LSCC have significantly lower incidence of laryngeal H. pylori infection and cagA 
      virulence factor than those without LSCC. Findings from this study support the 
      protective effect of H. pylori infection against laryngeal cancer.
FAU - Amizadeh, Maryam
AU  - Amizadeh M
AD  - Department of Otorhinolaryngology, Kerman University of Medical Sciences, Kerman, 
      Iran.
FAU - Shamsadini, Ayeh
AU  - Shamsadini A
AD  - Department of Otorhinolaryngology, Kerman University of Medical Sciences, Kerman, 
      Iran.
FAU - Arabzadeh, Aliakbar
AU  - Arabzadeh A
AD  - Department of Medical Microbiology, Kerman University of Medical Sciences, 
      Kerman, Iran.
FAU - Jazayeri, Seyedbehzad
AU  - Jazayeri S
AD  - Farzan Clinical Research Institute, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140820
PL  - India
TA  - Indian J Otolaryngol Head Neck Surg
JT  - Indian journal of otolaryngology and head and neck surgery : official publication 
      of the Association of Otolaryngologists of India
JID - 9422551
PMC - PMC4298619
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - Laryngeal cancer
OT  - SCC
OT  - cagA
EDAT- 2015/01/27 06:00
MHDA- 2015/01/27 06:01
PMCR- 2016/03/01
CRDT- 2015/01/27 06:00
PHST- 2014/05/11 00:00 [received]
PHST- 2014/07/11 00:00 [accepted]
PHST- 2015/01/27 06:00 [entrez]
PHST- 2015/01/27 06:00 [pubmed]
PHST- 2015/01/27 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 750 [pii]
AID - 10.1007/s12070-014-0750-2 [doi]
PST - ppublish
SO  - Indian J Otolaryngol Head Neck Surg. 2015 Mar;67(Suppl 1):51-5. doi: 
      10.1007/s12070-014-0750-2. Epub 2014 Aug 20.