PMID- 25622588 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150713 LR - 20181113 IS - 1598-2998 (Print) IS - 2005-9256 (Electronic) IS - 1598-2998 (Linking) VI - 47 IP - 3 DP - 2015 Jul TI - Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study. PG - 480-8 LID - 10.4143/crt.2014.058 [doi] AB - PURPOSE: The purpose of this study is to evaluate the prognostic role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and the need for para-aortic lymphadectomy in patients with primary fallopian tube carcinoma (PFTC). MATERIALS AND METHODS: Ninety-one patients with a diagnosis of PFTC were identified through the gynecologic oncology service database of six academic centers. Clinicopathological, surgical, and complete blood count data were collected. RESULTS: In univariate analysis, advanced stage, suboptimal surgery, and NLR > 2.7 were significant prognostic factors for progression-free survival, whereas in multivariate analysis, only advanced stage and suboptimal surgery were significant. In addition, in univariate analysis, cancer antigen 125 >/= 35 U/mL, ascites, advanced stage, suboptimal surgery, NLR > 2.7, PLR > 233.3, platelet count >/= 400,000 cells/mm(3), staging type, and histological subtype were significant prognostic factors for overall survival (OS); however, in multivariate analysis, only advanced stage, suboptimal surgery, NLR > 2.7, and staging type were significant. Inclusion of pelvic and para-aortic lymphadenectomy in surgery showed significant association with longer OS, with a mean and median OS of 42.0 months and 35.5 months (range, 22 to 78 months), respectively, vs. 33.5 months and 27.5 months (range, 14 to 76 months), respectively, for patients who underwent surgery without para-aortic lymphadenectomy (hazard ratio, 3.1; 95% confidence interval, 1.4 to 5.7; p=0.002). CONCLUSION: NLR (in both univariate and multivariate analysis) and PLR (only in univariate analysis) were prognostic factors in PFTC. NLR and PLR are inexpensive and easy tests to perform. In addition, patients with PFTC who underwent bilateral pelvic and para-aortic lymphadenectomy had longer OS. FAU - Gungorduk, Kemal AU - Gungorduk K AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Ertas, Ibrahim E AU - Ertas IE AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Ozdemir, Aykut AU - Ozdemir A AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Akkaya, Emrah AU - Akkaya E AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Telli, Elcin AU - Telli E AD - Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey. FAU - Taskin, Salih AU - Taskin S AD - Department of Gynecologic Oncology, Ankara University School of Medicine, Ankara, Turkey. FAU - Gokcu, Mehmet AU - Gokcu M AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Guzel, Ahmet Baris AU - Guzel AB AD - Department of Gynecologic Oncology, Cukurova University School of Medicine, Adana, Turkey. FAU - Oge, Tufan AU - Oge T AD - Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey. FAU - Akman, Levent AU - Akman L AD - Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey. FAU - Toptas, Tayfun AU - Toptas T AD - Department of Gynecologic Oncology, Akdeniz University School of Medicine, Antalya, Turkey. FAU - Solmaz, Ulas AU - Solmaz U AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Dogan, Askin AU - Dogan A AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Terek, Mustafa Cosan AU - Terek MC AD - Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey. FAU - Sanci, Muzaffer AU - Sanci M AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Ozsaran, Aydin AU - Ozsaran A AD - Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey. FAU - Simsek, Tayyup AU - Simsek T AD - Department of Gynecologic Oncology, Akdeniz University School of Medicine, Antalya, Turkey. FAU - Vardar, Mehmet Ali AU - Vardar MA AD - Department of Gynecologic Oncology, Cukurova University School of Medicine, Adana, Turkey. FAU - Yalcin, Omer Tarik AU - Yalcin OT AD - Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey. FAU - Ozalp, Sinan AU - Ozalp S AD - Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey. FAU - Yildirim, Yusuf AU - Yildirim Y AD - Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey. FAU - Ortac, Firat AU - Ortac F AD - Department of Gynecologic Oncology, Ankara University School of Medicine, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20141117 PL - Korea (South) TA - Cancer Res Treat JT - Cancer research and treatment JID - 101155137 PMC - PMC4506112 OTO - NOTNLM OT - Neutrophil lymphocyte ratio OT - Platelet lymphocyte ratio OT - Primary fallopian tube carcinoma OT - Prognostic factor OT - Retroperitoneal lymphadenectomy COIS- Conflict of interest relevant to this article was not reported. EDAT- 2015/01/28 06:00 MHDA- 2015/01/28 06:01 PMCR- 2015/07/01 CRDT- 2015/01/28 06:00 PHST- 2014/03/06 00:00 [received] PHST- 2014/05/01 00:00 [accepted] PHST- 2015/01/28 06:00 [entrez] PHST- 2015/01/28 06:00 [pubmed] PHST- 2015/01/28 06:01 [medline] PHST- 2015/07/01 00:00 [pmc-release] AID - crt.2014.058 [pii] AID - crt-2014-058 [pii] AID - 10.4143/crt.2014.058 [doi] PST - ppublish SO - Cancer Res Treat. 2015 Jul;47(3):480-8. doi: 10.4143/crt.2014.058. Epub 2014 Nov 17.