PMID- 25624017 OWN - NLM STAT- MEDLINE DCOM- 20160509 LR - 20160511 IS - 1868-6982 (Electronic) IS - 1868-6974 (Linking) VI - 22 IP - 8 DP - 2015 Aug TI - Diagnosis of functioning pancreaticoduodenal neuroendocrine tumors. PG - 602-9 LID - 10.1002/jhbp.209 [doi] AB - Functioning pancreaticoduodenal neuroendocrine tumors (PD-NETs) are popular in a textbook, but they are still unfamiliar to a general clinician, and delay of diagnosis or misdiagnosis has been reported even today. It is a consensus that sporadic functioning PD-NET is cured only by surgical resection. So, early detection and early resection is the gold standard for the treatment of functioning PD-NET. Functioning PD-NETs in patients with multiple endocrine neoplasia type 1 (MEN 1) are often multiple. You should check about MEN 1 whenever you encountered multiple PD-NET. They are diagnosed in younger age than sporadic cases. In most cases they are accompanied with numerous microscopic or macroscopic nonfunctioning P-NETs, which are potentially metastatic and the most common cause of death in MEN 1 patients. CI - (c) 2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery. FAU - Imamura, Masayuki AU - Imamura M AD - Neuroendocrine Tumor Center, Kansai Electric Power Hospital, 2-1-7 Fukushima, Fukushima, Osaka, 553-0003, Japan. FAU - Nakamoto, Yuji AU - Nakamoto Y AD - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Uose, Suguru AU - Uose S AD - Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Komoto, Izumi AU - Komoto I AD - Neuroendocrine Tumor Center, Kansai Electric Power Hospital, 2-1-7 Fukushima, Fukushima, Osaka, 553-0003, Japan. AD - Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan. FAU - Awane, Masaaki AU - Awane M AD - Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan. FAU - Taki, Yoshiro AU - Taki Y AD - Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan. LA - eng PT - Journal Article DEP - 20150126 PL - Japan TA - J Hepatobiliary Pancreat Sci JT - Journal of hepato-biliary-pancreatic sciences JID - 101528587 SB - IM MH - Diagnosis, Differential MH - Duodenal Neoplasms/*diagnosis/physiopathology MH - Glucagonoma/diagnosis MH - Humans MH - Insulinoma/diagnosis MH - Multiple Endocrine Neoplasia Type 1/diagnosis MH - Neuroendocrine Tumors/*diagnosis/physiopathology MH - Pancreatic Neoplasms/*diagnosis/physiopathology OTO - NOTNLM OT - Functioning duodenal neuroendocrine tumor OT - Functioning pancreaticoduodenal neuroendocrine tumor OT - Gastrinoma OT - Insulinoma EDAT- 2015/01/28 06:00 MHDA- 2016/05/10 06:00 CRDT- 2015/01/28 06:00 PHST- 2014/10/23 00:00 [received] PHST- 2014/12/11 00:00 [accepted] PHST- 2015/01/28 06:00 [entrez] PHST- 2015/01/28 06:00 [pubmed] PHST- 2016/05/10 06:00 [medline] AID - 10.1002/jhbp.209 [doi] PST - ppublish SO - J Hepatobiliary Pancreat Sci. 2015 Aug;22(8):602-9. doi: 10.1002/jhbp.209. Epub 2015 Jan 26.