PMID- 25624167
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20240512
IS  - 1479-6821 (Electronic)
IS  - 1351-0088 (Print)
IS  - 1351-0088 (Linking)
VI  - 22
IP  - 2
DP  - 2015 Apr
TI  - Persistent organic pollutants and obesity: are they potential mechanisms for 
      breast cancer promotion?
PG  - R69-86
LID - 10.1530/ERC-14-0411 [doi]
AB  - Dietary ingestion of persistent organic pollutants (POPs) is correlated with the 
      development of obesity. Obesity alters metabolism, induces an inflammatory tissue 
      microenvironment, and is also linked to diabetes and breast cancer risk/promotion 
      of the disease. However, no direct evidence exists with regard to the correlation 
      among all three of these factors (POPs, obesity, and breast cancer). Herein, we 
      present results from current correlative studies indicating a causal link between 
      POP exposure through diet and their bioaccumulation in adipose tissue that 
      promotes the development of obesity and ultimately influences breast cancer 
      development and/or progression. Furthermore, as endocrine disruptors, POPs could 
      interfere with hormonally responsive tissue functions causing dysregulation of 
      hormone signaling and cell function. This review highlights the critical need for 
      advanced in vitro and in vivo model systems to elucidate the complex relationship 
      among obesity, POPs, and breast cancer, and, more importantly, to delineate their 
      multifaceted molecular, cellular, and biochemical mechanisms. Comprehensive in 
      vitro and in vivo studies directly testing the observed correlations as well as 
      detailing their molecular mechanisms are vital to cancer research and, 
      ultimately, public health.
CI  - (c) 2015 Society for Endocrinology.
FAU - Reaves, Denise K
AU  - Reaves DK
AD  - Department of BiologyNorth Carolina Central University, MTSC Room 2247, 1801 
      Fayetteville Street, Durham, North Carolina 27707, USANational Cancer 
      InstituteNational Institutes of Health, Center for Cancer Training, Bethesda, 
      Maryland 20892, USADepartment of BiologyNorth Carolina Central University, 
      Durham, North Carolina 27707, USA.
FAU - Ginsburg, Erika
AU  - Ginsburg E
AD  - Department of BiologyNorth Carolina Central University, MTSC Room 2247, 1801 
      Fayetteville Street, Durham, North Carolina 27707, USANational Cancer 
      InstituteNational Institutes of Health, Center for Cancer Training, Bethesda, 
      Maryland 20892, USADepartment of BiologyNorth Carolina Central University, 
      Durham, North Carolina 27707, USA.
FAU - Bang, John J
AU  - Bang JJ
AD  - Department of BiologyNorth Carolina Central University, MTSC Room 2247, 1801 
      Fayetteville Street, Durham, North Carolina 27707, USANational Cancer 
      InstituteNational Institutes of Health, Center for Cancer Training, Bethesda, 
      Maryland 20892, USADepartment of BiologyNorth Carolina Central University, 
      Durham, North Carolina 27707, USA.
FAU - Fleming, Jodie M
AU  - Fleming JM
AD  - Department of BiologyNorth Carolina Central University, MTSC Room 2247, 1801 
      Fayetteville Street, Durham, North Carolina 27707, USANational Cancer 
      InstituteNational Institutes of Health, Center for Cancer Training, Bethesda, 
      Maryland 20892, USADepartment of BiologyNorth Carolina Central University, 
      Durham, North Carolina 27707, USA Jodie.fleming@nccu.edu.
LA  - eng
GR  - U54 CA156735/CA/NCI NIH HHS/United States
GR  - R21 CA175783/CA/NCI NIH HHS/United States
GR  - Intramural NIH HHS/United States
GR  - SC2 GM102012/GM/NIGMS NIH HHS/United States
GR  - SC2 CA176585/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20150126
PL  - England
TA  - Endocr Relat Cancer
JT  - Endocrine-related cancer
JID - 9436481
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Breast Neoplasms/*metabolism
MH  - Diet
MH  - Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Obesity/*metabolism
PMC - PMC4352112
MID - NIHMS660031
OTO - NOTNLM
OT  - breast cancer
OT  - metabolism
OT  - obesity
OT  - persistent organic pollutants
COIS- Conflict of Interest The authors declare that they have no conflict of interest.
EDAT- 2015/01/28 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/08/01
CRDT- 2015/01/28 06:00
PHST- 2015/01/28 06:00 [entrez]
PHST- 2015/01/28 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - ERC-14-0411 [pii]
AID - 10.1530/ERC-14-0411 [doi]
PST - ppublish
SO  - Endocr Relat Cancer. 2015 Apr;22(2):R69-86. doi: 10.1530/ERC-14-0411. Epub 2015 
      Jan 26.