PMID- 25624860
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150127
LR  - 20220310
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 10
IP  - 6
DP  - 2014 Dec 22
TI  - BDNF and HSP gene polymorphisms and their influence on the progression of primary 
      open-angle glaucoma in a Polish population.
PG  - 1206-13
LID - 10.5114/aoms.2014.45089 [doi]
AB  - INTRODUCTION: Glaucoma is a neurodegenerative disease that is often associated 
      with high intraocular pressure (IOP). One of the effects of elevated IOP is 
      disorder of neurotrophic molecules transport, including brain-derived 
      neurotrophic factor (BDNF) and recruit specific cellular proteins called "heat 
      shock proteins" (HSPs). The aim of this study was to evaluate a relationship 
      between the BDNF and HSP70-1 gene polymorphisms with risk occurrence of primary 
      open-angle glaucoma (POAG). MATERIAL AND METHODS: The study consisted of 167 
      patients with POAG (mean age: 73 +/-9) and 193 healthy subjects (mean age: 64 +/-13). 
      Genomic DNA was extracted from peripheral blood. Analysis of the gene 
      polymorphisms was performed using PCR-RFLP, using the following restriction 
      enzymes: NlaIII (rs6265) and BsrBI (rs1043618). The Heidelberg retinal tomography 
      (HRT) clinical parameters were also analyzed. The odds ratios (ORs) and 95% 
      confidence intervals (CIs) for each genotype and allele were calculated. RESULTS: 
      Comparison of the distributions of genotypes and alleles of the 196G/A 
      polymorphism of the BDNF gene as well as 190G/C polymorphism of the HSP70-1 gene 
      and analysis of the odds ratio (OR) showed no statistically significant 
      differences between POAG patients and controls (p > 0.05). However, there was a 
      statistically significant association of the 196G/A of BDNF and 190G/C of HSP70-1 
      gene polymorphisms with progression of POAG depending on values of clinical 
      parameters. 196G/A of BDNF correlated with the parameters GDx and RA (p = 0.03; p 
      = 0.002, respectively), while 190G/C of HSP70-1 correlated with c/d and RA (p = 
      0.014, p = 0.024, respectively). CONCLUSIONS: The BDNF 196G/A and HSP70-1 190G/C 
      gene polymorphisms may be related to progression of POAG.
FAU - Nowak, Alicja
AU  - Nowak A
AD  - Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 
      Poland.
FAU - Szaflik, Jacek P
AU  - Szaflik JP
AD  - Department of Ophthalmology II, Medical Faculty, Medical University of Warsaw, 
      Poland.
FAU - Gacek, Mira
AU  - Gacek M
AD  - Department of Ophthalmology II, Medical Faculty, Medical University of Warsaw, 
      Poland.
FAU - Przybylowska-Sygut, Karolina
AU  - Przybylowska-Sygut K
AD  - Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 
      Poland.
FAU - Kaminska, Anna
AU  - Kaminska A
AD  - Department of Ophthalmology II, Medical Faculty, Medical University of Warsaw, 
      Poland.
FAU - Szaflik, Jerzy
AU  - Szaflik J
AD  - Department of Ophthalmology II, Medical Faculty, Medical University of Warsaw, 
      Poland.
FAU - Majsterek, Ireneusz
AU  - Majsterek I
AD  - Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20140905
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC4296062
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - gene polymorphism
OT  - glaucoma
OT  - heat shock proteins
OT  - intraocular pressure
EDAT- 2015/01/28 06:00
MHDA- 2015/01/28 06:01
PMCR- 2014/12/22
CRDT- 2015/01/28 06:00
PHST- 2013/03/18 00:00 [received]
PHST- 2013/04/20 00:00 [revised]
PHST- 2013/05/30 00:00 [accepted]
PHST- 2015/01/28 06:00 [entrez]
PHST- 2015/01/28 06:00 [pubmed]
PHST- 2015/01/28 06:01 [medline]
PHST- 2014/12/22 00:00 [pmc-release]
AID - 23476 [pii]
AID - 10.5114/aoms.2014.45089 [doi]
PST - ppublish
SO  - Arch Med Sci. 2014 Dec 22;10(6):1206-13. doi: 10.5114/aoms.2014.45089. Epub 2014 
      Sep 5.