PMID- 25626601
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20150128
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 85
IP  - 2
DP  - 2015 Feb
TI  - Polymorphisms of HLA-A, -B, -Cw and DRB1 antigens in Moroccan patients with 
      ankylosing spondylitis and a comparison of clinical features with frequencies of 
      HLA-B*27.
PG  - 108-16
LID - 10.1111/tan.12515 [doi]
AB  - Ankylosing spondylitis (AS) is very often associated with human leukocyte antigen 
      (HLA), particularly HLA-B*27. However, the strength of this association and 
      clinical features may vary in different ethnic groups. Our study aims to assess 
      the distribution of HLA-A, -B, -Cw and DRB1 alleles in Moroccan patients with AS 
      and to compare the clinical features of AS and the frequencies of HLA-B27 in 
      patients from Morocco with other series. Seventy-five patients diagnosed with AS 
      and assessed for clinical manifestations were selected and compared to 100 
      healthy controls. HLA class I and II antigens were typed by polymerase chain 
      reaction sequence-specific oligonucleotide. HLA-B27 subtypes were studied by 
      polymerase chain reaction amplification with sequence-specific primers. HLA-B27 
      was found in 64% of patients. It was positively associated with younger age at 
      disease onset, family history, and uveitis while it had a negative association 
      with late onset. Six B*27 subtypes were identified in the AS group. HLA-B*2705 
      and B*2702 were the most common observed subtypes. Among other HLA genes, a 
      significant increase in the prevalence of HLA-Cw*02 and HLA-DRB*15 was found in 
      AS patients. HLA-B27 is involved in the predisposition of AS in the Moroccan 
      population. HLA-B*2705 and B*2702 were the predominant subtypes supporting 
      previous reports in Caucasian spondyloarthropathies. Other HLA genes, HLA-Cw*02 
      and HLA-DRB1*15, seem to confer predisposing effect to the disease. However, the 
      lower frequency of HLA-B27 compared to the literature in our study suggests the 
      existence of different genetic and/or environmental factors in Morocco.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - El Mouraghi, I
AU  - El Mouraghi I
AD  - Department of Biology, Faculty of Sciences, University Abdelmalek Essaidi, 
      Tetouan, Morocco.
FAU - Ouarour, A
AU  - Ouarour A
FAU - Ghozlani, I
AU  - Ghozlani I
FAU - Collantes, E
AU  - Collantes E
FAU - Solana, R
AU  - Solana R
FAU - El Maghraoui, A
AU  - El Maghraoui A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - HLA-A Antigens/*genetics
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - *Polymorphism, Genetic
MH  - Spondylitis, Ankylosing/*genetics
OTO - NOTNLM
OT  - HLA polymorphism
OT  - HLA-B27 subtypes
OT  - Moroccan population
OT  - ankylosing spondylitis
OT  - clinical features
EDAT- 2015/01/30 06:00
MHDA- 2015/09/29 06:00
CRDT- 2015/01/29 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2014/10/29 00:00 [revised]
PHST- 2014/12/17 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
AID - 10.1111/tan.12515 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Feb;85(2):108-16. doi: 10.1111/tan.12515.