PMID- 25626666
OWN - NLM
STAT- MEDLINE
DCOM- 20150724
LR  - 20150128
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 47
IP  - 6
DP  - 2014 Nov-Dec
TI  - Immune reconstitution inflammatory syndrome in HIV and sporotrichosis 
      coinfection: report of two cases and review of the literature.
PG  - 806-9
LID - S0037-86822014000600806 [pii]
LID - 10.1590/0037-8682-0146-2014 [doi]
AB  - We report 2 cases of patients with immune reconstitution inflammatory syndrome 
      (IRIS) associated with cutaneous disseminated sporotrichosis and human 
      immunodeficiency virus (HIV) coinfection. The patients received specific 
      treatment for sporotrichosis. However, after 4 and 5 weeks from the beginning of 
      antiretroviral therapy, both patients experienced clinical exacerbation of skin 
      lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 
      positive) count and decreased viral load. Despite this exacerbation, subsequent 
      mycological examination after systemic corticosteroid administration did not 
      reveal fungal growth. Accordingly, they were diagnosed with IRIS. However, the 
      sudden withdrawal of the corticosteroids resulted in the recurrence of IRIS 
      symptoms. No serious adverse effects could be attributed to prednisone. We 
      recommend corticosteroid treatment for mild-to-moderate cases of IRIS in 
      sporotrichosis and HIV coinfection with close follow-up.
FAU - Lyra, Marcelo Rosandiski
AU  - Lyra MR
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Nascimento, Maria Leticia Fernandes Oliveira
AU  - Nascimento ML
AD  - Departamento de Doencas Infecciosas, Hospital Central do Exercito, Rio de 
      Janeiro, RJ, Brasil.
FAU - Varon, Andrea Gina
AU  - Varon AG
AD  - Laboratorio de Micobacteria, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Pimentel, Maria Ines Fernandes
AU  - Pimentel MI
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Antonio, Liliane de Fatima
AU  - Antonio Lde F
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Saheki, Mauricio Naoto
AU  - Saheki MN
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Bedoya-Pacheco, Sandro Javier
AU  - Bedoya-Pacheco SJ
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
FAU - Valle, Antonio Carlos Francesconi do
AU  - Valle AC
AD  - Laboratorio de Vigilancia em Leishmanioses, Instituto Nacional de Infectologia 
      Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
SB  - IM
MH  - Adult
MH  - CD4 Lymphocyte Count
MH  - Coinfection
MH  - HIV Infections/*complications/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/immunology
MH  - Male
MH  - Sporotrichosis/*etiology/immunology
MH  - Viral Load
MH  - Young Adult
EDAT- 2015/01/30 06:00
MHDA- 2015/07/25 06:00
CRDT- 2015/01/29 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/07/25 06:00 [medline]
AID - S0037-86822014000600806 [pii]
AID - 10.1590/0037-8682-0146-2014 [doi]
PST - ppublish
SO  - Rev Soc Bras Med Trop. 2014 Nov-Dec;47(6):806-9. doi: 
      10.1590/0037-8682-0146-2014.